Effect of Intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis

1Associate Professor, Fellowship of Pain Medicine, Program Director of Pain Fellowship, Anesthesiology Research Center and Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Orthopaedics Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Anesthesiology Research Center, Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 2, issue 2; e149541

Published online:May 12, 2017

Article type:Original Articles

How to Cite:Masoud HashemiSeyed Amir MohajeraniPayman DadkhahEffect of Intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis.J Cell Mol Anesth.2(2):e149541.https://doi.org/10.22037/jcma.v2i2.16016.

Abstract

Introduction: Knee Osteoarthrosis is one of the most debilitating diseases. Prolotherapy includes intraarticular injection of various drugs to decrease inflammation. Injection of Intradiscal O2-O3 has reduced pain and disability of patients with low back pain due to prolapsed lumbar disk. Objective: To compare the effect of intraarticular injection of Ozone and steroids in improvement of clinical and cellular healing of knee osteoarthritis. Methods: in a randomized clinical trial, 70 patients with knee osteoarthrosis were included in the study. In Ozone group, 5 ml (35 ?g/ml) of Ozone and in steroid group 5ml (50 mg) Triamcinolone were injected intraarticular. At 1,2,and 6 month patients were followed for pain scale, disability index and IL-1? and TNF-? serum levels were measured. Results: At 1 month after injection pain scale and disability index and IL-1? and TNF-? were decreased in both groups. However, at 2 and 6 month pain scale and disability index were significantly lower in Ozone group compare to steroid group (p

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Author(s):

Masoud Hashemi:[PubMed][Scholar]
Seyed Amir Mohajerani:[PubMed][Scholar]
Payman Dadkhah:[PubMed][Scholar]