Burden of Congenital Factor XIII Deficiency in Iran

Akbar Dorgalaleh

doi:10.22037/jcma.v2i3.16263

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v2i3.16263

Burden of Congenital Factor XIII Deficiency in Iran

Author(s):

Akbar Dorgalaleh¹

1Student Research Committee, Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 2, issue 3; e149544

Published online:Aug 07, 2017

Article type:Review

How to Cite:Dorgalaleh A, Burden of Congenital Factor XIII Deficiency in Iran.J Cell Mol Anesth.2017;2(3):e149544.https://doi.org/10.22037/jcma.v2i3.16263.

Abstract

Congenital factor XIII (FXIII) deficiency is a rare coagulopathy with the highest incidence in Iran. Iranian patients with FXIII deficiency (FXIIID) presented high rate of bleeding episodes, some of them are major cause of disability and mortality among these patients. Hemarthrosis and intracranial hemorrhage (ICH) can affect activity and social productivity of patients. ICH, recurrent miscarriage and umbilical cord bleeding are the major cause of mortality. Hematoma, and prolonged menstrual bleeding as well as post-surgical bleeding are other significant bleeding in Iranian patients with FXIIID. Present of severe life threatening bleeding episodes and other notable bleedings, can significantly reduce working activities and social productivities of patients. Although Iranian patients with FXIIID, experienced significant diseases related complications, early diagnosis accompany by appropriate therapeutic regimes can prevent most of these problems.

Keywords

Congenital Factor XIII Deficiency

coagulopathy

References

1.
References are in the PDF file of the article.

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Author(s):

Akbar Dorgalaleh:[PubMed][Scholar]