The Effect of Pulsatile Blood Flow During Proximal Graft, on Liver Function in Coronary Artery Bypass Graft Surgery

Seyed Mohammadreza Amouzegar Zavareh; Marzieh Lak

doi:10.22037/jcma.v3i3.17329

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v3i3.17329

The Effect of Pulsatile Blood Flow During Proximal Graft, on Liver Function in Coronary Artery Bypass Graft Surgery

Author(s):

Seyed Mohammadreza Amouzegar Zavareh^1,*,

Marzieh Lak²

1Assistant Professor, Department of Anesthesiology, Faculty of Medical Science, Tehran,

2Associate Professor, Department of Anesthesiology, Faculty of Medical Science, Tehran,

Journal of Cellular & Molecular Anesthesia:Vol. 3, issue 3; e149550

Published online:Nov 04, 2018

Article type:Original Articles

How to Cite:Amouzegar Zavareh S M, Lak M, The Effect of Pulsatile Blood Flow During Proximal Graft, on Liver Function in Coronary Artery Bypass Graft Surgery.J Cell Mol Anesth.2018;3(3):e149550.https://doi.org/10.22037/jcma.v3i3.17329.

Abstract

Background: Liver dysfunction is a rare complication with high mortality and morbidity in coronary artery bypass grafting (CABG) surgery. Pulsatile blood flow probably maintains liver function during cardiopulmonary bypass (CPB).Methods: In this randomized clinical trial study, 68 patients who were underwent CABG surgery divided in two groups: pulsatile and non-pulsatile groups. We transferred continuous blood flow to pulsatile blood flow during proximal graft by using cardiac contraction.Results: There was not significant difference in serum-alanine-aminotransferase (SGPT) and alkaline phosphatase (ALP) values at variable times in two groups. In addition, the procedure of SGPT and ALP in the case and control groups was not significantly different in three days. There was not significant difference in serum glutamic oxaloacetic transaminase (SGOT) values at variable times in two groups. However, the procedure of SGOT in the case group was significantly increased and in control group was not significantly different in three days.Conclusion: we conclude that hemodynamic stability is more important than type of blood flow in maintaining liver function.Keywords: pulsatile perfusion, cardio pulmonary bypass, liver function

Keywords

pulsatile perfusion

cardio pulmonary bypass

liver function

References

1.
References are in the PDF file of the article.

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Author(s):

Seyed Mohammadreza Amouzegar Zavareh:[PubMed][Scholar]
Marzieh Lak:[PubMed][Scholar]