Comparing the use of Memantine with Dextromethorphan and Placebo to Reduce Pain before Orthopedic Surgery

Mehrdad Taheri; Alireza Mirkheshti; Mohammad Khak; Yalda Adili

doi:10.22037/jcma.v2i4.18182

Journal of Cellular & Molecular Anesthesia

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement New Publisher Announcement Reviewer and AE Registration Form Contact Us Support

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/jcma.v2i4.18182

Comparing the use of Memantine with Dextromethorphan and Placebo to Reduce Pain before Orthopedic Surgery

Author(s):

Mehrdad Taheri

^1,*,

Alireza Mirkheshti²,

Mohammad Khak

³,

Yalda Adili²

1Assistant Professor of Anesthesia; Fellowship of Pain, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Orthopedics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 2, issue 4; e149554

Published online:Dec 11, 2017

Article type:Original Articles

How to Cite:Mehrdad TaheriAlireza MirkheshtiMohammad KhakYalda AdiliComparing the use of Memantine with Dextromethorphan and Placebo to Reduce Pain before Orthopedic Surgery.J Cell Mol Anesth.2(4):e149554.https://doi.org/10.22037/jcma.v2i4.18182.

Abstract

Introduction: To compare the use of Memantine with Dextromethorphan and placebo to reduce pain after orthopedic surgery.Materials and Methods: The present study was a double-blind clinical trial including180 patients undergoing elective orthopedic surgery of the lower limbs. Patients were divided randomly into three groups of 60 patients each. The first group (Group M) received 30 mg Memantine orally, the second group (Group D) received 45 mg of Dextromethorphan and the third group (Group P) received only placebo, two and a half hours before the operation. The intensity of pain (VAS score), sedation score, and nausea and vomiting were recorded postoperatively.Results: In this study, 60 patients were enrolled in each group. The total VAS (Visual Analogue Scale) score was significantly lower among patients receiving Memantine and the satisfaction was significantly higher compared to the Dextromethorphan and placebo groups (P-value <0.001).Conclusion: The present study results indicate that Memantine has a relatively better outcome compared to Dextromethorphan or placebo in reducing the post surgical pain among patients undergoing orthopedic surgeries. It also reduced the need for post surgical opioid use and improved the patients? satisfaction.??

Keywords

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Mehrdad Taheri:[PubMed][Scholar]
Alireza Mirkheshti:[PubMed][Scholar]
Mohammad Khak:[PubMed][Scholar]
Yalda Adili:[PubMed][Scholar]