Comparison of Two Methods of Bolus and Infusion of Tranexamic Acid in Reduction of Blood Loss in Total Knee Arthroplasty

Mohammadreza Moshari; Bahman Malek; Mohammadreza Minator Sajjadi; Maryam Vosoughian; Mastaneh Dahi Taleghani; Mahshid Ghasemi; Razieh Shekari

doi:10.22037/jcma.v3i1.18430

Journal of Cellular & Molecular Anesthesia

Current Issue All Issues Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form New Publisher Announcement Support Contact Us

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/jcma.v3i1.18430

Comparison of Two Methods of Bolus and Infusion of Tranexamic Acid in Reduction of Blood Loss in Total Knee Arthroplasty

Author(s):

Mohammadreza Moshari^1,*,

Bahman Malek¹,

Mohammadreza Minator Sajjadi¹,

Maryam Vosoughian

²,

Mastaneh Dahi Taleghani

³,

Mahshid Ghasemi

¹,

Razieh Shekari⁴

1MD, Assistant Professor, Anesthesiology Research Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran

2MD, Associate Professor, Anesthesiology Research Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran

3MD, Associate Professor,Anesthesiology Research Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran

4MD, Anesthesiology Research Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 3, issue 1; e149556

Published online:Jan 31, 2018

Article type:Original Articles

How to Cite:Moshari M, Malek B, Minator Sajjadi M, Vosoughian M, Dahi Taleghani M, et al. Comparison of Two Methods of Bolus and Infusion of Tranexamic Acid in Reduction of Blood Loss in Total Knee Arthroplasty. J Cell Mol Anesth. 2018;3(1):e149556. doi: https://doi.org/10.22037/jcma.v3i1.18430

Abstract

AbstractBackground:?So far, many studies?have been performed?to determine the optimal dose and regimen of?tranexamic acid to reduce?preoperative and postoperative blood loss in primary total knee?arthroplasty. In the present?study, two different methods of administration (bolus and infusion),?were?compared.Materials and Methods:?Forty patients were randomized in?the two groups?(A and B)?of 20 patients each. All patients received 500 mg?tranexamic acid before?inflation of?tourniquet. Group A (mean age,?64? 6.1 years) received 500 mg tranexamic acid?10?minutes before?loosening of?tourniquet and?group B (mean age,?63.5 ? 7.7 years) received 500 mg?tranexamic acid?through?IV infusion during 6 hours from the?time of tourniquet loosening (total dose of TA,?1 g in both groups). Intraoperative blood loss,postoperative drainage (in 6 and 12 hours), blood transfusion (in 48 hours),?and decrease in?hematocrit?and?hemoglobin?(6 and 12 hours later),?were compared between?the?two groups.Results:?The patients in group B had?lower?intra- and postoperative?blood loss?in 6 and 12?hours and also had?lower decrease in?hemoglobin,?and?their?packed cell transfusion rate was significantly?lower compared to?the?group A.Conclusion:?The findings of this?study?indicated?that infusion administration of tranexamic acid in?primary total knee arthroplasty,?was more effective?in the reduction of?perioperative blood loss?as well as?need?for blood transfusion in 48 hours.

Keywords

Tranexamic Acid

Total Knee Arthroplasty

Postoperative Blood Loss

References

1.
References are in the PDF file of the article.

Is Intra-Articular Administration of Fibrinogen Effective in Postoperative Total Knee Arthroplasty Blood Loss? A Randomized Clinical Trial

Farahzad Janatmakan,

Fatemeh Javaherforooshzadeh,

Mohsen Khorrami,

Sara Jarirahmadi,

Hojjatollah Khademali

Janatmakan F, Javaherforooshzadeh F, Khorrami M, Jarirahmadi S, Khademali H. Is Intra-Articular Administration of Fibrinogen Effective in Postoperative Total Knee Arthroplasty Blood Loss? A Randomized Clinical Trial. Anesth Pain Med. 2020;11(1):e107431. doi: https://doi.org/10.5812/aapm.107431

22

Oct

2019

Comparison Effect of Tranexamic Acid (TA) and Tranexamic Acid Combined with Vitamin C (TXC) on Drainage Volume and Atrial Fibrillation Arrhythmia in Patients Undergoing Cardiac Bypass Surgery: Randomized Clinical Trial

Koorosh Ghorbaninezhad,

Fozieh Bakhsha,

Zahra Yousefi,

Solmaz Halakou,

Zahra Mehrbakhsh

Ghorbaninezhad K, Bakhsha F, Yousefi Z, Halakou S, Mehrbakhsh Z. Comparison Effect of Tranexamic Acid (TA) and Tranexamic Acid Combined with Vitamin C (TXC) on Drainage Volume and Atrial Fibrillation Arrhythmia in Patients Undergoing Cardiac Bypass Surgery: Randomized Clinical Trial. Anesth Pain Med. 2019;9(5):e96096. doi: https://doi.org/10.5812/aapm.96096

20

Jan

2026

Comparative Study of the Effects of Local Tranexamic Acid (TXA) and Placebo in Reducing Bleeding in Patients Undergoing TURP Surgery

Mohsen Sarkarian,

Kamran Shehni Nezhadpour,

Sirous Rafiei Asl

Sarkarian M, Shehni Nezhadpour K, Rafiei Asl S. Comparative Study of the Effects of Local Tranexamic Acid (TXA) and Placebo in Reducing Bleeding in Patients Undergoing TURP Surgery. Nephro-Urol Mon. 2026;18(1):e167956. doi: https://doi.org/10.5812/numonthly-167956

2

Jul

2023

Evaluating the Efficacy and Safety of a Single-Dose Tranexamic Acid in Reducing Blood Loss During Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: A Randomized Comparative Pilot Study

Ehab Hanafy Shaker,

Ahmed Mohamed Soliman,

Ahmed Fahmy Hussein,

Ehab Samy Fayek,

Mai Mohamed Elrawas

Shaker EH, Soliman AM, Hussein AF, Fayek ES, Elrawas MM. Evaluating the Efficacy and Safety of a Single-Dose Tranexamic Acid in Reducing Blood Loss During Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: A Randomized Comparative Pilot Study. Anesth Pain Med. 2023;13(4):e136578. doi: https://doi.org/10.5812/aapm-136578

15

Dec

2020

Comparing Vancomycin-Tranexamic Acid Paste to Vancomycin- Normal Saline Paste in Reducing Post Coronary Artery Bypass Graft Surgery Bleeding

Amir Mirmohammadsadeghi,

Hafez Asadollahi

Mirmohammadsadeghi A, Asadollahi H. Comparing Vancomycin-Tranexamic Acid Paste to Vancomycin- Normal Saline Paste in Reducing Post Coronary Artery Bypass Graft Surgery Bleeding. Int Cardiovasc Res J. 2020;14(4):e103103. doi:

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 3
Last Update: 0 months ago
Scopus by Title: 0
Last Update: 0 months ago
Scopus by Title (Ref): 0
Last Update: 0 months ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Mohammadreza Moshari:[PubMed][Scholar]
Bahman Malek:[PubMed][Scholar]
Mohammadreza Minator Sajjadi:[PubMed][Scholar]
Maryam Vosoughian:[PubMed][Scholar]
Mastaneh Dahi Taleghani:[PubMed][Scholar]
Mahshid Ghasemi:[PubMed][Scholar]
Razieh Shekari:[PubMed][Scholar]

Outlines

Comparison of Two Methods of Bolus and Infusion of Tranexamic Acid in Reduction of Blood Loss in Total Knee Arthroplasty

Abstract

References

Similar Articles

Is Intra-Articular Administration of Fibrinogen Effective in Postoperative Total Knee Arthroplasty Blood Loss? A Randomized Clinical Trial

Comparison Effect of Tranexamic Acid (TA) and Tranexamic Acid Combined with Vitamin C (TXC) on Drainage Volume and Atrial Fibrillation Arrhythmia in Patients Undergoing Cardiac Bypass Surgery: Randomized Clinical Trial

Comparative Study of the Effects of Local Tranexamic Acid (TXA) and Placebo in Reducing Bleeding in Patients Undergoing TURP Surgery

Evaluating the Efficacy and Safety of a Single-Dose Tranexamic Acid in Reducing Blood Loss During Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: A Randomized Comparative Pilot Study

Comparing Vancomycin-Tranexamic Acid Paste to Vancomycin- Normal Saline Paste in Reducing Post Coronary Artery Bypass Graft Surgery Bleeding

Crossmark

Checking

Last Update: 0 months ago

Last Update: 0 months ago

Last Update: 0 months ago

Last Update: 3 days ago