The relationship between s100? and cerebral oximetry trend in patients undergoing CABG with cardiopulmonary bypass

authors:

avatar Kamal Fani ORCID 1 , * , avatar Hedayatollah Elyasi 2 , avatar Hossein Ali Jelveh Moghaddam 3 , avatar Golnar Radmand 4 , avatar Mahnoosh Foroughi ORCID 5 , avatar Samira Rajaei ORCID 6 , avatar Ali Dabbagh ORCID 7

MD, Assistant Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Resident of Anesthesiology, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Assistant Professor, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MSc, Biostatistician, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Associate Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, PhD, Associate Professor, Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Islamic Republic of Iran
Professor of Cardiac Anesthesia; Editor in Chief, JCMA Anesthesiology Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.3, issue 2; e149557
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v3i2.20625

how to cite: Fani K, Elyasi H, Jelveh Moghaddam H A, Radmand G, Foroughi M, et al. The relationship between s100? and cerebral oximetry trend in patients undergoing CABG with cardiopulmonary bypass. J Cell Mol Anesth. 2018;3(2):e149557. https://doi.org/10.22037/jcma.v3i2.20625.

Abstract

Background: CABG is among the most common cardiac procedures often done as on pump surgery. There are however, there is always the risk for potential neurologic and neurocognitive insults in CABG. S100? is a biomarker for CNS damage. Cerebral oximetry using NIRS has been developed for CNS monitoring especially cardiac surgery. This study was designed to find the relationship between serum levels of s100? and cerebral oximetry in CABG patients.Methods: in an observational study, 44 adult 40-75 years patients entered the study for elective CABG. Serum levels of s100? were assessed at two times during CPB; i.e. just after aortic clamping and immediately after aortic declamping; while the results were compared with right and left cerebral oximetry readings (NIRS); however, NIRS was measured at baseline, during start of cardiopulmonary bypass (CPB), during aortic clamping, and finally at off-clamping the aorta. Repeated Measures ANCOVA (analysis of covariance), multiple linear regression models and Spearman correlation coefficient with scatter plot were used for data analysis. P value less than 0.05 considered significant.Results: no linear correlation between s100? and NIRS was found according to correlation coefficients. Only among the patients whose s100? was more than 10, the scatter plots demonstrated a positive linear relationship between s100? and right NIRS (spearman correlation coefficient= 0.792; P value=0.006).Conclusions: the study failed to demonstrate a relationship between on-CPB NIRS numbers and serum s100? in adult patients undergoing CABG during the bypass interval; further studies are suggested to evaluate potential predictive value of NIRS in brain ischemia.