Epidural Anesthesia with Lidocaine and Dexmedetomidine, Versus Lidocaine Alone on Plasma Levels of IL-6 in Patients with Proximal Femoral Fracture.

authors:

avatar Mohammadreza Moshari 1 , * , avatar Bahman Malek 1 , avatar Adel Ebrahimpour ORCID 2 , avatar Maryam Vosoughian 1 , avatar Mastaneh Dahi Taleghani ORCID 1 , avatar ehsan ghorbani 1 , avatar Seyed Mohammad Seyed-Alshohadaei 1

Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran
Department of Orthopaedic Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran
Journal of Cellular & Molecular Anesthesia: Vol.3, issue 3; e149561
published online: November 04, 2018
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v3i3.21115

how to cite: Moshari M, Malek B, Ebrahimpour A , Vosoughian M, Dahi Taleghani M, et al. Epidural Anesthesia with Lidocaine and Dexmedetomidine, Versus Lidocaine Alone on Plasma Levels of IL-6 in Patients with Proximal Femoral Fracture.. J Cell Mol Anesth. 2018;3(3):e149561. https://doi.org/10.22037/jcma.v3i3.21115.

Abstract

Interleukin-6 plays an important role in inflammatory responses and synthesis of acute hepatic phase proteins and its plasma level changes are used as a reliable prognostic factor for mortality in hospitalized patients. On the other hand, various methods for reducing inflammatory responses, including proper control of pain during and after surgery, and correction of hemodynamic disorders, can be monitored by monitoring of plasma levels of IL-6. Epidural anesthesia is an appropriate method for controlling pain in lower limb surgeries. The aim of this study was to evaluate the effect of adding Dexmedetomidine to lidocaine in the epidural injection for better control of post-surgical inflammatory responses by measuring interleukin-6 plasma levels.Patients referred to Taleghani Hospital in 1396 who suffered from lower limb fractures and requiring surgery were evaluated. 52 patients in two groups receiving Dexmedetomidine doses of media and controls for the quality of epidural anesthesia and IL-6 index. After obtaining written consent, the Dexmedetomidine treatment group and the normal saline control group were prescribed epidural with lidocaine. Finally, the level of IL-6 before surgery and 6 hours after surgery were evaluated.According to the results of statistical analysis, the two groups did not show a significant difference in age and level of interleukin prior to the operation. The mean age of patients in this study was 15.84639 ? 53.4038. The sex distribution of the study included 19 women (36.5%) and 33 men (63.5%). According to the U Mann Whitney test, the second injection time and total drug volume had a significant difference between the control and intervention groups and Dexmedetomidine reduced the volume of total drug needed and increase the time interval until the second injection (p <0.001). There was also a significant difference between the two groups in the level of interleukin 6 after 6 hours of operation and this was lower in the Dexmedetomidine group.keywords: Interleukin-6, Dexmedetomidine, lidocaine, Anesthesia

References

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