The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia

authors:

avatar Mohammadreza Moshari ORCID 1 , avatar Samira Rajaei ORCID 2 , avatar Maryam Vosoughian ORCID 3 , avatar Hedayatollah Elyasi 3

Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Immunology Dept. TUMS, Tehran, Iran
Anesthesiology Research Center, SBMU, Tehran, Iran
Warning: No corresponding author defined!
Journal of Cellular & Molecular Anesthesia: Vol.3, issue 3; e149563
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v3i3.22580

how to cite: Moshari M, Rajaei S, Vosoughian M, Elyasi H. The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia. J Cell Mol Anesth. 2018;3(3):e149563. https://doi.org/10.22037/jcma.v3i3.22580.

Abstract

?Background: The purpose of this study is to investigate the impact of different anesthetic techniques on the release of cytokines interleukin IL-6, IL-10 and tumor necrosis factor (TNF)-? in preeclampsia patients who undergo cesarean section.Materials and Methods: In the study 40 patients were enrolled with preeclampsia undergoing cesarean section, allocated into two equal groups to receive either general anesthesia (n = 20) or spinal anesthesia (n = 20). Non-invasive hemodynamic monitoring was used. Serum levels of IL-6, IL-10 and TNF-? were measured before and at the end of surgery.Results: There was no significant rise in serum levels of TNF-? in general anesthesia while IL-6 and IL-10 serum levels increased significantly. Also, compared with patients anaesthetized with general anesthesia patients who received regional anesthesia notably had lower levels of IL-6 and IL-10 after surgery (p < 0.05).Conclusion: Spinal anesthesia causes significant difference in post-operation IL-6 and IL-10 serum levels in preeclampsia patients undergoing cesarean section. Nevertheless, neither general nor spinal anesthesia made such effect on serum level of TNF-?. Further studies with higher sample size and comparing preeclamptic patients to healthy mothers undergoing cesarean section are required.