The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia

Mohammadreza Moshari; Samira Rajaei; Maryam Vosoughian; Hedayatollah Elyasi

doi:10.22037/jcma.v3i3.22580

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v3i3.22580

The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia

Author(s):

Mohammadreza Moshari¹,

Samira Rajaei

²,

Maryam Vosoughian

³,

Hedayatollah Elyasi³

1Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Immunology Dept. TUMS, Tehran, Iran

3Anesthesiology Research Center, SBMU, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 3, issue 3; e149563

Published online:Nov 04, 2018

Article type:Original Articles

How to Cite:Moshari M, Rajaei S, Vosoughian M, Elyasi H, The Effect of Spinal and General Anesthesia on Cytokine Serum Levels Following Cesarean Section in Preeclampsia.J Cell Mol Anesth.2018;3(3):e149563.https://doi.org/10.22037/jcma.v3i3.22580.

Abstract

?Background: The purpose of this study is to investigate the impact of different anesthetic techniques on the release of cytokines interleukin IL-6, IL-10 and tumor necrosis factor (TNF)-? in preeclampsia patients who undergo cesarean section.Materials and Methods: In the study 40 patients were enrolled with preeclampsia undergoing cesarean section, allocated into two equal groups to receive either general anesthesia (n = 20) or spinal anesthesia (n = 20). Non-invasive hemodynamic monitoring was used. Serum levels of IL-6, IL-10 and TNF-? were measured before and at the end of surgery.Results: There was no significant rise in serum levels of TNF-? in general anesthesia while IL-6 and IL-10 serum levels increased significantly. Also, compared with patients anaesthetized with general anesthesia patients who received regional anesthesia notably had lower levels of IL-6 and IL-10 after surgery (p < 0.05).Conclusion: Spinal anesthesia causes significant difference in post-operation IL-6 and IL-10 serum levels in preeclampsia patients undergoing cesarean section. Nevertheless, neither general nor spinal anesthesia made such effect on serum level of TNF-?. Further studies with higher sample size and comparing preeclamptic patients to healthy mothers undergoing cesarean section are required.

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Author(s):

Mohammadreza Moshari:[PubMed][Scholar]
Samira Rajaei:[PubMed][Scholar]
Maryam Vosoughian:[PubMed][Scholar]
Hedayatollah Elyasi:[PubMed][Scholar]