Could molecular studies save Hydroxyethyl starch from total disappearance?

authors:

avatar Parisa Sezari ORCID 1 , * , avatar Kamran Mottaghi 1 , avatar Masoud Nashibi ORCID 1 , avatar Farhad Safari ORCID 1

Anesthesiology Research Center, Shahid Beheshti University of medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.3, issue 4; e149572
published online: February 22, 2019
article type: Review
DOI: https://doi.org/10.22037/jcma.v3i4.24282

how to cite: Sezari P, Mottaghi K, Nashibi M, Safari F. Could molecular studies save Hydroxyethyl starch from total disappearance?. J Cell Mol Anesth. 2018;3(4):e149572. https://doi.org/10.22037/jcma.v3i4.24282.

Abstract

Up until now, hydroxyethyl starch (HES) solutions have mainly been indicated as "volume expanders". Recent unfavorable reports of these solutions such as probability of kidney injury or inducing coagulopathy have relatively ejected these solutions in many centers, particularly in European countries. Despite several confirming studies, multiple anecdotal letters or reviews has challenged total disappearance of these colloids from medicine practice. Also, some novel observations emphasized the distinguished ability of HES to preserve the microvascular integrity even at the presence of an inflammatory process. Despite extreme statements has been published demanding immediate suspension of these fluids from the market, it seems logical to revise the most recent studies which may declare new pathways to approach HES family of solutions.?

References

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    References are in the PDF file of the article.