Could molecular studies save Hydroxyethyl starch from total disappearance?

Parisa Sezari; Kamran Mottaghi; Masoud Nashibi; Farhad Safari

doi:10.22037/jcma.v3i4.24282

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v3i4.24282

Could molecular studies save Hydroxyethyl starch from total disappearance?

Author(s):

Parisa Sezari

^1,*,

Kamran Mottaghi¹,

Masoud Nashibi

¹,

Farhad Safari

¹

1Anesthesiology Research Center, Shahid Beheshti University of medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 3, issue 4; e149572

Published online:Feb 22, 2019

Article type:Review

How to Cite:Parisa SezariKamran MottaghiMasoud NashibiFarhad SafariCould molecular studies save Hydroxyethyl starch from total disappearance?.J Cell Mol Anesth.2019;3(4):e149572.https://doi.org/10.22037/jcma.v3i4.24282.

Abstract

Up until now, hydroxyethyl starch (HES) solutions have mainly been indicated as "volume expanders". Recent unfavorable reports of these solutions such as probability of kidney injury or inducing coagulopathy have relatively ejected these solutions in many centers, particularly in European countries. Despite several confirming studies, multiple anecdotal letters or reviews has challenged total disappearance of these colloids from medicine practice. Also, some novel observations emphasized the distinguished ability of HES to preserve the microvascular integrity even at the presence of an inflammatory process. Despite extreme statements has been published demanding immediate suspension of these fluids from the market, it seems logical to revise the most recent studies which may declare new pathways to approach HES family of solutions.?

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Author(s):

Parisa Sezari:[PubMed][Scholar]
Kamran Mottaghi:[PubMed][Scholar]
Masoud Nashibi:[PubMed][Scholar]
Farhad Safari:[PubMed][Scholar]