A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors

authors:

avatar Farhad Safari ORCID 1 , * , avatar Parisa Sezari ORCID 2 , avatar Kamran Mottaghi ORCID 3 , avatar Bahareh Torbat Isfahani ORCID 4 , avatar Masoud Nashibi ORCID 2

Associate Professor, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Assistant Professor,Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Associate Professor, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran..
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Cellular & Molecular Anesthesia: Vol.4, issue 1; e149576
published online: August 15, 2019
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v4i1.25315

how to cite: Safari F, Sezari P, Mottaghi K, Torbat Isfahani B, Nashibi M. A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors. J Cell Mol Anesth. 2019;4(1):e149576. https://doi.org/10.22037/jcma.v4i1.25315.

Abstract

Background: The purpose of this randomized, single-center study was to prospectively investigate the impact of anesthetic techniques for craniotomy on the release of cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor factor-alpha (TNF-?)) and to determine whether intravenous anesthesia compared to inhalational anesthesia attenuates the inflammatory response.Methods and Materials: The study enrolled 60 patients undergoing craniotomy, allocated into two equal groups to receive either Isoflurane (n=30) and Propofol (n=30). Non-invasive hemodynamic monitoring was used. Serum levels of IL-1, IL-6 and TNF-? were evaluated before and at the end of surgery and anesthesia.Results: Although there was a significant rise in serum level of inflammatory cytokine but compared with patients anaesthetized with Isoflurane, patients who received Propofol had significant lower levels of IL-1, IL-6 and TNF-a after surgery (p<0.05).Conclusion: Patients who received Propofol had lower levels of IL-1, IL-6 and TNF-? after surgery. Our findings should incite future studies to prove a potential medically important anti-inflammatory role of Propofol in neuroanesthesia.

References

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    References are in the PDF file of the article.