A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors

Farhad Safari; Parisa Sezari; Kamran Mottaghi; Bahareh Torbat Isfahani; Masoud Nashibi

doi:10.22037/jcma.v4i1.25315

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v4i1.25315

A comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors

Author(s):

Farhad Safari

^1,*,

Parisa Sezari

²,

Kamran Mottaghi

³,

Bahareh Torbat Isfahani

⁴,

Masoud Nashibi

²

1Associate Professor, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2Assistant Professor,Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3Associate Professor, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran..

4Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Cellular & Molecular Anesthesia:Vol. 4, issue 1; e149576

Published online:Aug 15, 2019

Article type:Original Articles

How to Cite:Farhad SafariParisa SezariKamran MottaghiBahareh Torbat IsfahaniMasoud NashibiA comparative study of influence of isoflurane and propofol on IL1, IL6, TNF serum levels after craniotomy for supratentorial brain tumors.J Cell Mol Anesth.4(1):e149576.https://doi.org/10.22037/jcma.v4i1.25315.

Abstract

Background: The purpose of this randomized, single-center study was to prospectively investigate the impact of anesthetic techniques for craniotomy on the release of cytokines (interleukin (IL)-1, IL-6, tumor necrosis factor factor-alpha (TNF-?)) and to determine whether intravenous anesthesia compared to inhalational anesthesia attenuates the inflammatory response.Methods and Materials: The study enrolled 60 patients undergoing craniotomy, allocated into two equal groups to receive either Isoflurane (n=30) and Propofol (n=30). Non-invasive hemodynamic monitoring was used. Serum levels of IL-1, IL-6 and TNF-? were evaluated before and at the end of surgery and anesthesia.Results: Although there was a significant rise in serum level of inflammatory cytokine but compared with patients anaesthetized with Isoflurane, patients who received Propofol had significant lower levels of IL-1, IL-6 and TNF-a after surgery (p<0.05).Conclusion: Patients who received Propofol had lower levels of IL-1, IL-6 and TNF-? after surgery. Our findings should incite future studies to prove a potential medically important anti-inflammatory role of Propofol in neuroanesthesia.

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Author(s):

Farhad Safari:[PubMed][Scholar]
Parisa Sezari:[PubMed][Scholar]
Kamran Mottaghi:[PubMed][Scholar]
Bahareh Torbat Isfahani:[PubMed][Scholar]
Masoud Nashibi:[PubMed][Scholar]