Effect of combined Conventional Ultrafiltration and Modified Ultrafiltration on Serum Interleukin-6 and TNF-? Levels in Pediatric Cardiac Surgery Patients

Mehran Shahzamani; Ramin Baghaei; Ali Dabbagh; Kamal Fani; Mahnoosh Foroughi; Mansour Pourmohsen

doi:10.22037/jcma.v4i1.26197

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v4i1.26197

Effect of combined Conventional Ultrafiltration and Modified Ultrafiltration on Serum Interleukin-6 and TNF-? Levels in Pediatric Cardiac Surgery Patients

Author(s):

Mehran Shahzamani^1,*,

Ramin Baghaei²,

Ali Dabbagh

³,

Kamal Fani

³,

Mahnoosh Foroughi⁴,

Mansour Pourmohsen¹

1Cardiac Surgery Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan

2Cardiac Surgery Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran

3Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran

4Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran

Journal of Cellular & Molecular Anesthesia:Vol. 4, issue 1; e149577

Published online:Aug 15, 2019

Article type:Original Articles

How to Cite:Mehran ShahzamaniRamin BaghaeiAli DabbaghKamal FaniMahnoosh ForoughiMansour Pourmohsenet al.Effect of combined Conventional Ultrafiltration and Modified Ultrafiltration on Serum Interleukin-6 and TNF-? Levels in Pediatric Cardiac Surgery Patients.J Cell Mol Anesth.4(1):e149577.https://doi.org/10.22037/jcma.v4i1.26197.

Abstract

AbstractBackground: Water retention occurs in most of the congenital heart surgery patients, especially in pediatrics. Ultrafiltration excretes water, electrolytes, many free radicals and inflammatory mediators. The aim of this study was to investigate the effect of modified ultrafiltration (MUF) on the serum levels of TNF-? and IL-6 in pediatrics patients undergoing congenital heart surgeries.Methods and Materials: A total of 91 pediatric congenital heart disease patients candidate for total correction were selected and divided randomly in two groups: CUF (Conventional Ultrafiltration) and CUF+MUF; 40 patients were allocated to CUF group and 51 patients to CUF+MUF group. Serum levels of TNF-? and IL-6 were assessed before CPB and 6 hours after the end of the operation in ICU. Postoperative levels of TNF-? and IL-6 were compared between the two groups.Results: In the MUF+CUF group, the preoperative and postoperative TNF-? levels were 2.5?5.6 and 1.4?3.0 respectively. However, IL-6 serum levels before and after operation were 4.8?8.9 and 41?56. In the CUF only group, the TNF-? level before and after surgery was 3.1?6.2 and 1.0?0.44; respectively; similarly, IL-6 serum levels were 3.3?8.2 and 34.8?37.7.Conclusion: MUF in congenital heart surgery could filtrate excess water and elevate hematocrit but does not have a definitive role in reducing TNF-? and IL-6 serum levels.Keywords: MUF, TNF-?, IL-6, CUF, cardiopulmonary bypass

Keywords

Ultrafiltration

Interleukin-6

TNF-alpha

Congenital Heart Defect

Cardiopulmonary Bypass

Heart Surgery

References

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References are in the PDF file of the article.

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Author(s):

Mehran Shahzamani:[PubMed][Scholar]
Ramin Baghaei:[PubMed][Scholar]
Ali Dabbagh:[PubMed][Scholar]
Kamal Fani:[PubMed][Scholar]
Mahnoosh Foroughi:[PubMed][Scholar]
Mansour Pourmohsen:[PubMed][Scholar]