The role of connective tissue genomics in ascending aortic dissection: A case of Marfan syndrome

authors:

avatar Firoozeh Madadi ORCID 1 , * , avatar manouchehr hekmat 2 , avatar Zahra Ansari Aval ORCID 3 , avatar Abdolhamid Bagheri 4 , avatar Kamal Fani ORCID 5 , avatar Mohammad Hosein Ghanbarpour 6 , avatar maryam hamidzad 7 , avatar Mehrubon Murodov 8 , avatar Ali Dabbagh ORCID 9

MD, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Associate Professor, Department of Cardiac Surgery, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Assistant Professor, Department of Cardiac Surgery, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Assistant Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Assistant Professor of Cardiac Anesthesia, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Assistant Professor, Anesthesiology Department, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
MD, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Republican Scientific Center of Cardiovascular Surgery, Dushanbe, Tajikistan
Professor of Cardiac Anesthesia, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.4, issue 3; e149588
article type: Brief Communications
DOI: https://doi.org/10.22037/jcma.v4i3.28189

how to cite: Madadi F, hekmat M, Ansari Aval Z , Bagheri A, Fani K, et al. The role of connective tissue genomics in ascending aortic dissection: A case of Marfan syndrome. J Cell Mol Anesth. 2019;4(3):e149588. https://doi.org/10.22037/jcma.v4i3.28189.

Abstract

Background: Aortic dissection is a rare yet life threating condition with some already discovered risk factors namely hypertension, connective tissue disorders such as Marfan syndrome (MFS), cocaine abuse and cigarette smoking.Case report: In this article we would like to present a case of MFS who presented with severe chest pain and undergone Bentall surgery due to aortic dissection and aneurysm.Conclusion: Although many risk factors and preventive measures are already investigated, there is no definite method to avoid its occurrence in genetically predisposed patients such as MFS. Patient-specific models utilizing embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) may offer some advantages.