Assessing the effects of dexmedetomidine and labetalol on changes in heart rate and blood pressure after laryngoscopy compared to a control group

Behzad Nazemroaya; Mitra Jabalameli; Arsham Kamali

doi:10.22037/jcma.v5i2.29271

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v5i2.29271

Assessing the effects of dexmedetomidine and labetalol on changes in heart rate and blood pressure after laryngoscopy compared to a control group

Author(s):

Behzad Nazemroaya

^1,*,

Mitra Jabalameli²,

Arsham Kamali³

11. Assistant Professor, Department of Anesthesiology and Critical Care , School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

2Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3Student of Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 5, issue 2; e149597

Published online:Mar 25, 2020

Article type:Original Articles

How to Cite:Behzad NazemroayaMitra JabalameliArsham KamaliAssessing the effects of dexmedetomidine and labetalol on changes in heart rate and blood pressure after laryngoscopy compared to a control group.J Cell Mol Anesth.5(2):e149597.https://doi.org/10.22037/jcma.v5i2.29271.

Abstract

Background: One of the objectives of a smooth laryngoscopy is to minimize hemodynamic changes. The goal of this study was to assess the effects of dexmedetomidine and labetalol on heart rate and blood pressure changes after laryngoscopy compared to a control group. Materials and Methods: This was a double-blind clinical trial conducted on 120 patients aged between 18 and 60 years, who were candidates for surgery, under general anesthesia, at Alzahra hospital in Isfahan during 2017-2018. Patients were randomly allocated to three groups of being administered dexmedetomidine or labetalol and a control group. The patient's age, weight, height, gender and clinical data including mean blood pressure (BP), heart rate, systolic BP, diastolic BP and oxygen saturation during 1, 3, 5 and 10 minutes after intubation were collected and analyzed using repeated measure analysis. Results: The average age of patients who were candidates for surgery was 42.62 +/- 1.40. 52 percent (63 patients) were male subjects. The results showed no significant difference in mean BP, diastolic BP, systolic BP or oxygen saturation (p>0.05) in the three groups. But the difference in heart rate between the three groups was statistically significant. The heart rate in the dexmedetomidine group was significantly lower than the labetalol and control groups (p=0.00). Conclusion: Results of the current study showed that using labetalol provided desirable hemodynamic stability compared to dexmedetomidine and caused less hemodynamic disturbances.

Keywords

dexmedetomidine

labetalol

laryngoscopy

References

1.
References are in the PDF file of the article.

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Author(s):

Behzad Nazemroaya:[PubMed][Scholar]
Mitra Jabalameli:[PubMed][Scholar]
Arsham Kamali:[PubMed][Scholar]