Outline
The effects of Ropivacaine and its Combination with Dexmedetomidine and Dexamethasone on Neural Apoptosis
Authors
2, Faramarz Mosaffa1, Shideh Dabir1, seyed mohammad seyed alshohadaei1, Fereshteh Baghizadeh1Abstract
Background: Neurotoxicity effects of anesthetics in different age groups is a major concern regarding neural injuries. It is reasonable to recognize the neurotoxicity risks of anesthetic drugs and their combinations. Materials and Methods: A total of 16 mice (Mus musculus) weighing 22 to 30 gr were randomly divided into four drug groups (control, Ropivacaine, Ropivacaine + Dexmedetomidine, Ropivacaine + Dexamethasone). 24 hours after unilateral injection of drugs into the femoral nerve of mice, the mice were killed and their femoral nerve was removed. Hematoxylin-eosin tissue staining was used to evaluate changes in the effects of the drugs, and nerve samples were extracted to measure TLR4 and caspase 3 expressions. After Western blotting, the protein expression level was checked between different groups. Results: Ropivacaine in combination with dexamethasone caused less damage to the rat nerve cells. The combination of ropivacaine with dexamethasone (p=0.53 and p=0.46) compared to the combination of ropivacaine with dexmedetomidine relatively had better results in terms of cytotoxicity. Conclusion: A combination of ropivacaine with dexamethasone reduces neurotoxicity risk.
Highlights
References
- 1.References are in the PDF file of the article.
Copyright
© 2020, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Effect of bupivacaine and combination with dexmedetomidine and dexamethasone on mice neural apoptosis
Moshari M, Dabbagh A, Dahi Taleghani M, Vosoughian M, Hosseini B, et al. Effect of bupivacaine and combination with dexmedetomidine and dexamethasone on mice neural apoptosis. J Cell Mol Anesth. 2019;4(3):e149589. doi: https://doi.org/10.22037/jcma.v4i3.28282
Comparing Analgesic Efficacy: Ropivacaine with Dexamethasone vs. Ropivacaine with Dexmedetomidine After Cesarean Section Using Transversus Abdominis Plane Block (2020 - 2021)
Jamshidi M, Ghaderi M, Hojatansari M. Comparing Analgesic Efficacy: Ropivacaine with Dexamethasone vs. Ropivacaine with Dexmedetomidine After Cesarean Section Using Transversus Abdominis Plane Block (2020 - 2021). Anesth Pain Med. 2024;14(5):e147872. doi: https://doi.org/10.5812/aapm-147872
Randomized Control Trial Using Ropivacaine in Spinal Anaesthesia With and Without Intravenous Dexmedetomidine in Lower Limb Surgeries
MS A. Randomized Control Trial Using Ropivacaine in Spinal Anaesthesia With and Without Intravenous Dexmedetomidine in Lower Limb Surgeries. J Cell Mol Anesth. 2020;5(3):e149631. doi: https://doi.org/10.22037/jcma.v5i3.30971
Evaluation of Adding Dexmedetomidine to Ropivacaine in Pediatric Caudal Epidural Block: A Randomized, Double-blinded Clinical Trial
Imani F, Farahmand Rad R, Salehi R, Alimian M, Mirbolook Jalali Z, et al. Evaluation of Adding Dexmedetomidine to Ropivacaine in Pediatric Caudal Epidural Block: A Randomized, Double-blinded Clinical Trial. Anesth Pain Med. 2021;11(1):e112880. doi: https://doi.org/10.5812/aapm.112880
A Comparison of Different Doses Efficacy of Isobaric Ropivacaine 0.5% in Spinal Anesthesia in Cesarean Section
Golfam P, Yari M, Prezidend N, Gheitury B, Rezaei M. A Comparison of Different Doses Efficacy of Isobaric Ropivacaine 0.5% in Spinal Anesthesia in Cesarean Section. J Kermanshah Univ Med Sci. 2024;28(4):e142126. doi: https://doi.org/10.5812/jkums-142126
- Scopus by DOI: 4
Last Update: 1 week ago
- Scopus by Title: 4
Last Update: 1 week ago
- Scopus by Title (Ref): 4
Last Update: 1 week ago
- CrossRef: 0
Last Update: 6 days ago