The Effects of Vitamin D3 in Pediatric Patients Undergoing Congenital Heart Surgery

Hossein Ali Jelveh Moghaddam; Kamal Fani; Dr Hekmat; Amir Azari

doi:10.22037/jcma.v5i2.30306

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v5i2.30306

The Effects of Vitamin D3 in Pediatric Patients Undergoing Congenital Heart Surgery

Author(s):

Hossein Ali Jelveh Moghaddam^1,*,

Kamal Fani

¹,

Dr Hekmat

²,

Amir Azari³

1Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Cardiac Surgery Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 5, issue 2; e149624

Published online:May 08, 2020

Article type:Original Articles

How to Cite:Hossein Ali Jelveh MoghaddamKamal FaniDr HekmatAmir AzariThe Effects of Vitamin D3 in Pediatric Patients Undergoing Congenital Heart Surgery.J Cell Mol Anesth.5(2):e149624.https://doi.org/10.22037/jcma.v5i2.30306.

Abstract

Background: To investigate the effects of vitamin D3 on the surgical outcome of pediatric patients undergoing cardiac surgery for congenital heart conditions. Materials and Methods: Ninety pediatric cardiac surgery patients referred for preoperative evaluation were enrolled. Patients with insufficient vitamin D3 levels received intramuscular vitamin D3 (300,000 IU) three days before the surgery and those with final vitamin D3 level of ?30 ng/dl were included and divided into 3 groups (Group A: abnormal Vit D levels, no Vit D treatment; Group B: abnormal Vit D levels, Vit D treatment up to normal serum Vit D levels before surgery; Group C: normal baseline Vit D levels, no supplemental Vit D treatment). Interleukin 1, 6, 10, tumor necrosis factor-alpha, vital signs, and arterial blood gas parameters were measured before the surgery and at 6 and 24 hours after cardiopulmonary bypass. Data on total hospital stay, reoperation rates, and inotropes scores were retrieved. Additionally, postoperative measures including hemodynamic factors, blood pressure, heart rate, cardiac output, electrocardiography changes, chest-tube drainage, and ventilation-related factors (i.e. respiratory rate, arterial blood gas, respiratory resistance, intubation time, ?) were recorded. Results: We observed a significant increase in post cardiopulmonary bypass levels of IL-10 and IL-6 in all groups (p<0.002) regardless of vitamin D treatment status; however, no significant difference was seen in levels of IL-1 and TNF-alpha. Groups B had more patients with critical levels of VIS scores compared to groups A and C (p<0.002). Furthermore, no differences in hemodynamic and metabolic parameters were observed. Conclusion: No significant difference in the rates of postoperative parameters in patients with normal and those with deficient levels of vitamin D3 was observed.

Keywords

Vitamin D

Congenital heart disease (CHD)

Cardiac surgery

Cardiopulmonary bypass

Vitamin D3 supplementation

References

1.
References are in the PDF file of the article.

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Author(s):

Hossein Ali Jelveh Moghaddam:[PubMed][Scholar]
Kamal Fani:[PubMed][Scholar]
Dr Hekmat:[PubMed][Scholar]
Amir Azari:[PubMed][Scholar]