The Effects of Vitamin D3 in Pediatric Patients Undergoing Congenital Heart Surgery

authors:

avatar Hossein Ali Jelveh Moghaddam 1 , * , avatar Kamal Fani ORCID 1 , avatar Dr Hekmat ORCID 2 , avatar Amir Azari 3

Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cardiac Surgery Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.5, issue 2; e149624
published online: May 08, 2020
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v5i2.30306

how to cite: Jelveh Moghaddam H A, Fani K, Hekmat D, Azari A. The Effects of Vitamin D3 in Pediatric Patients Undergoing Congenital Heart Surgery. J Cell Mol Anesth. 2020;5(2):e149624. https://doi.org/10.22037/jcma.v5i2.30306.

Abstract

Background: To investigate the effects of vitamin D3 on the surgical outcome of pediatric patients undergoing cardiac surgery for congenital heart conditions. Materials and Methods: Ninety pediatric cardiac surgery patients referred for preoperative evaluation were enrolled. Patients with insufficient vitamin D3 levels received intramuscular vitamin D3 (300,000 IU) three days before the surgery and those with final vitamin D3 level of ?30 ng/dl were included and divided into 3 groups (Group A: abnormal Vit D levels, no Vit D treatment; Group B: abnormal Vit D levels, Vit D treatment up to normal serum Vit D levels before surgery; Group C: normal baseline Vit D levels, no supplemental Vit D treatment). Interleukin 1, 6, 10, tumor necrosis factor-alpha, vital signs, and arterial blood gas parameters were measured before the surgery and at 6 and 24 hours after cardiopulmonary bypass. Data on total hospital stay, reoperation rates, and inotropes scores were retrieved. Additionally, postoperative measures including hemodynamic factors, blood pressure, heart rate, cardiac output, electrocardiography changes, chest-tube drainage, and ventilation-related factors (i.e. respiratory rate, arterial blood gas, respiratory resistance, intubation time, ?) were recorded. Results: We observed a significant increase in post cardiopulmonary bypass levels of IL-10 and IL-6 in all groups (p<0.002) regardless of vitamin D treatment status; however, no significant difference was seen in levels of IL-1 and TNF-alpha. Groups B had more patients with critical levels of VIS scores compared to groups A and C (p<0.002). Furthermore, no differences in hemodynamic and metabolic parameters were observed. Conclusion: No significant difference in the rates of postoperative parameters in patients with normal and those with deficient levels of vitamin D3 was observed.

References

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