Effect of Dexmedetomidine on Transcription Factors and Inflammatory Cytokines in Elective Aortic Aneurysm Repair Surgery

authors:

avatar Faranak Behnaz ORCID 1 , * , avatar ronak karbalaeifar 2 , avatar Azita Chegini ORCID 3 , avatar Gholamreza Mohseni ORCID 4 , avatar Samad Valizadeh 5

Assistant professor of anesthesiology, Anesthesiology research center, Shahid Beheshti university of medical sciences, Tehran, Iran
Resident of anesthesiology, Anesthesiology research center, Shahid Beheshti university of medical sciences, Tehran, Iran
Assistant professor of anesthesiology, Blood transfusion research center, High Institute for Research and education in transfusion medicine, Tehran, Iran
Associated professor of anesthesiology, Anesthesiology research center, Shahid Beheshti university of medical sciences, Tehran, Iran
Blood transfusion research center, High Institute for Research and education in transfusion medicine, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.5, issue 3; e149629
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v5i3.30882

how to cite: Behnaz F, karbalaeifar R, Chegini A, Mohseni G, Valizadeh S. Effect of Dexmedetomidine on Transcription Factors and Inflammatory Cytokines in Elective Aortic Aneurysm Repair Surgery. J Cell Mol Anesth. 2020;5(3):e149629. https://doi.org/10.22037/jcma.v5i3.30882.

Abstract

Background: Aortic clamping during abdominal aortic aneurysm repair surgery leads to complications such as systemic inflammatory response (SIRS) and dysfunction in various vital organs. This study aimed to investigate the effect of dexmedetomidine infusion on transcription factors and inflammatory cytokines during elective open abdominal aortic aneurysm repair surgery. Materials and Methods: A prospective, clinical trial performed on patients with abdominal aortic aneurysm surgery, which were divided into two groups (dexmedetomidine, 8 patients and control, 12 patients). Demographic characteristics, biochemical laboratory variables, fluid and blood transfusions during surgery, and levels of inflammatory cytokines and expression of inflammatory genes were evaluated and compared in both groups. Results: There were no significant differences between the two groups regarding demographic characteristics, biochemical laboratory variables, fluids, and blood transfusions during surgery (P> 0.05). The level of inflammatory cytokines and the expression of inflammatory genes in both groups decreased significantly after surgery (P <0.05). However, the level of inflammatory cytokines and the expression of inflammatory genes in the dexmedetomidine group were significantly lower at the end of the surgery (P <0.05). Conclusion: In abdominal aortic aneurysm surgery, dexmedetomidine could significantly reduce complications of clamping during surgery, which may result in hemodynamic stability and prevent significant inflammatory response to surgical stress and organ damage following ischemia-reperfusion damage.