The Effect of Dexmedetomidine Infusion vs. Morphine on Duration of Mechanical Ventilation in CABG: A Clinical Trial

Gholamreza Massoumi; Amir Reza Hemasian; Mojtaba Mansouri

doi:10.22037/jcma.v6i1.31553

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v6i1.31553

The Effect of Dexmedetomidine Infusion vs. Morphine on Duration of Mechanical Ventilation in CABG: A Clinical Trial

Author(s):

Gholamreza Massoumi^1,*,

Amir Reza Hemasian²,

Mojtaba Mansouri³

1Associate Professor of Cardiac Anesthesia Department of Anesthesiology, School of Medicine Anesthesiology and Critical Care Research Center Chamran Hospital Isfahan University of Medical Sciences

2Resident of Anesthesiology, Department of Anesthesiology, Faculty of Medicine, University of Isfahan of Medical Sciences Isfahan, Iran

3Professor of Anesthesiology, Department of Anesthesiology, Faculty of Medicine, University of Isfahan of Medical Sciences Isfahan, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 6, issue 1; e149638

Published online:Sep 05, 2020

Article type:Original Articles

How to Cite:Massoumi G, Hemasian AR, Mansouri M. The Effect of Dexmedetomidine Infusion vs. Morphine on Duration of Mechanical Ventilation in CABG: A Clinical Trial. J Cell Mol Anesth. 2021;6(1):e149638. doi: https://doi.org/10.22037/jcma.v6i1.31553

Abstract

Background: No single and ideal method has been proposed so far to decrease the time of mechanical ventilation while maintaining patients' hemodynamic stability after coronary bypass surgery. This study aimed to compare the effect of Dexmedetomidine and Morphine infusion on the latter parameters in patients after coronary artery bypass graft surgery in the intensive care unit. Materials and Methods: In this clinical trial study, 60 patients undergoing coronary artery bypass graft surgery were divided into two groups (N=30): the first group receiving Morphine and the second group receiving Dexmedetomidine. At admission to the ICU in the first group, Morphine was injected at a dose of 0.25 mg/kg, and in the second group, Dexmedetomidine was injected at a dose of 1 ?g/kg for 10 minutes. Hemodynamic parameters and blood gas levels at preoperative cardiac care were compared between the two groups at the time of endotracheal tube withdrawal. Results: The trend of hemodynamic changes and blood gas levels during the intensive care unit stay did not differ between the two groups. The mean duration of mechanical ventilation in the Morphine group was 10.63/2 2.31 hours and in the Dexmedetomidine group was 9.77/1 1.92 hours, and there was no significant difference between the two groups (p=0.12). Conclusion: both Morphine and Dexmedetomidine had similar effects on hemodynamic stability and blood gas levels; however, Dexmedetomidine was associated with fewer drug-related side effects; so, it seems wise to consider Dexmedetomidine superior to Morphine in the postoperative period of CABG patients.

Keywords

Bypass; Coronary; Hemodynamic; Dexmedetomidine; Morphine

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Author(s):

Gholamreza Massoumi:[PubMed][Scholar]
Amir Reza Hemasian:[PubMed][Scholar]
Mojtaba Mansouri:[PubMed][Scholar]

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The Effect of Dexmedetomidine Infusion vs. Morphine on Duration of Mechanical Ventilation in CABG: A Clinical Trial

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