Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial

Mahboobeh  Darban; Farhad Malek; Mohammad Memarian; Ali Gohari; Arda Kiani; Alireza Emadi; Samaneh Lavvaf; Bahador Bagheri

doi:10.22037/jcma.v6i2.32182

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v6i2.32182

Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial

Author(s):

Mahboobeh Darban^1,*,

Farhad Malek¹,

Mohammad Memarian¹,

Ali Gohari²,

Arda Kiani³,

Alireza Emadi⁴,

Samaneh Lavvaf⁴,

Bahador Bagheri

⁵

1Department of Pulmonology, Kowsar Hospital, Semnan University of Medical sciences, Semnan, Iran

2Department of Infectious Diseases, Kowsar Hospital, Semnan University of Medical sciences, Semnan, Iran

3Department of Pulmonology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran

4Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran

5Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 6, issue 2; e149653

Published online:Dec 15, 2020

Article type:Brief Communications

How to Cite:Mahboobeh DarbanFarhad MalekMohammad MemarianAli GohariArda KianiAlireza EmadiSamaneh LavvafBahador Bagheriet al.Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial.J Cell Mol Anesth.6(2):e149653.https://doi.org/10.22037/jcma.v6i2.32182.

Abstract

INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19. METHODS:? Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. RESULTS: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between 2 groups (P > 0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although not significant. No significant difference was noted in length of ICU stay between 2 groups (P = 0.3). CONCLUSION: Our study suggests that addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19.?

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Author(s):

Mahboobeh Darban:[PubMed][Scholar]
Farhad Malek:[PubMed][Scholar]
Mohammad Memarian:[PubMed][Scholar]
Ali Gohari:[PubMed][Scholar]
Arda Kiani:[PubMed][Scholar]
Alireza Emadi:[PubMed][Scholar]
Samaneh Lavvaf:[PubMed][Scholar]
Bahador Bagheri:[PubMed][Scholar]