Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial

authors:

avatar Mahboobeh Darban 1 , * , avatar Farhad Malek 1 , avatar Mohammad Memarian 1 , avatar Ali Gohari 2 , avatar Arda Kiani 3 , avatar Alireza Emadi 4 , avatar Samaneh Lavvaf 4 , avatar Bahador Bagheri ORCID 5

Department of Pulmonology, Kowsar Hospital, Semnan University of Medical sciences, Semnan, Iran
Department of Infectious Diseases, Kowsar Hospital, Semnan University of Medical sciences, Semnan, Iran
Department of Pulmonology, Masih Daneshvari Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran
Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran
Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran
Journal of Cellular & Molecular Anesthesia: Vol.6, issue 2; e149653
article type: Brief Communications
DOI: https://doi.org/10.22037/jcma.v6i2.32182

how to cite: Darban M , Malek F, Memarian M, Gohari A, Kiani A, et al. Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol Anesth. 2021;6(2):e149653. https://doi.org/10.22037/jcma.v6i2.32182.

Abstract

INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19. METHODS:? Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. RESULTS: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between 2 groups (P > 0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although not significant. No significant difference was noted in length of ICU stay between 2 groups (P = 0.3). CONCLUSION: Our study suggests that addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19.?