Clinical Significance and Different Expression of Dipeptidyl Peptidase IV and Procalcitonin in Mild and Severe COVID-19

Hamidreza Jamaati; Payam Tabarsi; Naghmeh Bahrami; Fatemeh  Yasari; Mohammad  Varahram; Mehdi Kazempour Dizaji; Seyed Mohammadreza Hashemian; Mahya  Daustany; Maral  Emami; Sadegh Shirian; Ladan  Masumi; Amir  Rasouli; Armita  Narimani; Nasser   Ahmadian; Abdolreza Mohamadnia; Ali Akbar  Velayati

doi:10.22037/jcma.v6i2.34671

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v6i2.34671

Clinical Significance and Different Expression of Dipeptidyl Peptidase IV and Procalcitonin in Mild and Severe COVID-19

Author(s):

Hamidreza Jamaati

^,*,

Payam Tabarsi

,

Naghmeh Bahrami

,

Fatemeh Yasari,

Mohammad Varahram,

Mehdi Kazempour Dizaji,

Seyed Mohammadreza Hashemian,

Mahya Daustany ,

Maral Emami ,

Sadegh Shirian

,

Ladan Masumi ,

Amir Rasouli,

Armita Narimani,

Nasser Ahmadian,

Abdolreza Mohamadnia

¹,

Ali Akbar Velayati

1PhD of Molecular Medicine, Virology Research Center, National Research Institute of Tuberculosis & Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran

Journal of Cellular & Molecular Anesthesia:Vol. 6, issue 2; e149671

Published online:May 15, 2021

Article type:Original Articles

How to Cite:Hamidreza JamaatiPayam TabarsiNaghmeh BahramiFatemeh YasariMohammad VarahramMehdi Kazempour DizajiSeyed Mohammadreza HashemianMahya Daustany Maral Emami Sadegh ShirianLadan Masumi Amir RasouliArmita NarimaniNasser AhmadianAbdolreza MohamadniaAli Akbar Velayatiet al.Clinical Significance and Different Expression of Dipeptidyl Peptidase IV and Procalcitonin in Mild and Severe COVID-19.J Cell Mol Anesth.2021;6(2):e149671.https://doi.org/10.22037/jcma.v6i2.34671.

Abstract

Background: Coronavirus has become a global concern in 2019-20. The virus belongs to the coronavirus family, which has been able to infect many patients and victims around the world. The virus originated in the Chinese city of Wuhan, which eventually spread around the world and became a pandemic. Materials and Methods: A total of 60 Patients with severe (n=30) and mild (n=30) symptoms of COIVD-19 were included in this study. Peripheral blood samples were collected from the patients. Real-time PCR was used to compare the relative expression levels of Procalcitonin and dipeptidyl peptidase IV (DPPIV) in a patient with severe and mild Covid-19 infection. Results: Procalcitonin and dipeptidyl peptidase IV markers in the peripheral blood of patients with severe symptoms, were positive in 29 (96.60%) and 26 (86.60%), respectively (n=30); however, positive rates in the mild symptoms patients group were 27 (90%) and 25 (83.30%), respectively. There was a statistically significant difference between these two groups in terms of DDPIV and Procalcitonin (p<0.001). Conclusion: Procalcitonin and DPPIV increase in patients with COVID-19 infection, significantly higher in the patients with more severe clinical symptoms than those with milder ones. More studies will be needed to verify the reliability of the current findings. Keywords: Procalcitonin, DPPIV, Severe symptoms, Mild symptoms, COVID-19

Keywords

Procalcitonin

Dipeptidyl peptidase-4

Severe symptoms

Mild symptoms

COVID-19

References

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References are in the PDF file of the article.

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Author(s):

Hamidreza Jamaati:[PubMed][Scholar]
Payam Tabarsi:[PubMed][Scholar]
Naghmeh Bahrami:[PubMed][Scholar]
Fatemeh Yasari:[PubMed][Scholar]
Mohammad Varahram:[PubMed][Scholar]
Mehdi Kazempour Dizaji:[PubMed][Scholar]
Seyed Mohammadreza Hashemian:[PubMed][Scholar]
Mahya Daustany :[PubMed][Scholar]
Maral Emami :[PubMed][Scholar]
Sadegh Shirian:[PubMed][Scholar]
Ladan Masumi :[PubMed][Scholar]
Amir Rasouli:[PubMed][Scholar]
Armita Narimani:[PubMed][Scholar]
Nasser Ahmadian:[PubMed][Scholar]
Abdolreza Mohamadnia:[PubMed][Scholar]
Ali Akbar Velayati:[PubMed][Scholar]