Derangement of Basic Amino Acids and Nitric Oxide Levels in Patients Undergoing Cardiothoracic Surgery

Ahmed Farouk; Rasha Hamed; Nashwa  Farouk Abd El Hafez; Rania  Abdalla; Farag  Moftah; Fify Alfy Gabra; Tahia Saleem

doi:10.22037/jcma.v8i2.38772

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v8i2.38772

Derangement of Basic Amino Acids and Nitric Oxide Levels in Patients Undergoing Cardiothoracic Surgery

Author(s):

Ahmed Farouk^,*,

Rasha Hamed,

Nashwa Farouk Abd El Hafez,

Rania Abdalla,

Farag Moftah,

Fify Alfy Gabra,

Tahia Saleem¹

1Professor

Journal of Cellular & Molecular Anesthesia:Vol. 8, issue 2; e149676

Published online:Sep 22, 2022

Article type:Original Articles

How to Cite:Ahmed FaroukRasha HamedNashwa Farouk Abd El HafezRania AbdallaFarag MoftahFify Alfy GabraTahia Saleemet al.Derangement of Basic Amino Acids and Nitric Oxide Levels in Patients Undergoing Cardiothoracic Surgery.J Cell Mol Anesth.8(2):e149676.https://doi.org/10.22037/jcma.v8i2.38772.

Abstract

Background: A cyclic relationship exists, between; arginine, citrulline, and ornithine. Arginase is a specific enzyme that plays a role in this relationship. This study aimed to elucidate the role of surgical trauma and anesthesia on plasma levels of the previous acids and nitric oxide (NO) and to determine whether the changes in these levels can be correlated to the duration of surgery and anesthesia exposure. Patients and methods: The study included: group A 41 patients who underwent coronary bypasses and group B 17 patients who underwent lung cancer surgery. The amino acid analyzer was used for the detection of amino acids, while NO was estimated by a Spectro-photometric method. Results: The study revealed a significant decrease in the intra-operative levels of arginine, citrulline, ornithine, and NO compared to their pre-operative levels in both groups. Conclusion: Depletion of these basic amino acids is possibly multifunctional and can be associated with an increase in arginase, surgical trauma, anesthesia, and stress.

Keywords

Basic Amino acids

Nitric Oxide

cardiothoracic and surgical trauma

References

1.
References are in the PDF file of the article.

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Author(s):

Ahmed Farouk:[PubMed][Scholar]
Rasha Hamed:[PubMed][Scholar]
Nashwa Farouk Abd El Hafez:[PubMed][Scholar]
Rania Abdalla:[PubMed][Scholar]
Farag Moftah:[PubMed][Scholar]
Fify Alfy Gabra:[PubMed][Scholar]
Tahia Saleem:[PubMed][Scholar]