Abstract
Aim and Background: Remote Ischemic Preconditioning introduces brief episodes of ischemia and reperfusion which reduces long term ischemia in orthopaedic surgery. The aim of this study was to evaluate hemodynamic and respiratory effects of remote ischemic preconditioning in lower extremity orthopaedic surgeries.Methods: In this clinical trial 40 patients scheduled for lower extremity surgery with pneumatic tourniquet were randomly allocated to remote ischemic preconditioning (RIP group, n=20) and control group (n=19). Patients in RIP group received three ?5 minutes? cycles of ischemia, alternating with 5 minutes of reperfusion before extended use of tourniquet. Hemodynamic variables prior to inflation of tourniquet, every 30 minutes during the surgery and 10 minutes after tourniquet deflation and also arterial blood gas sample prior to and after surgery were recorded and compared between groups.Results: During operation blood pressure dropped in the RIP group and variations in heart rate, respiratory rate and pulse oximeter measurements after surgical tourniquet release were not significantly different between two groups. Changes in blood gas parameters were significantly less pronounced in the RIP group.Conclusion: Remote ischemic preconditioning may not attenuate most of the adverse effects of surgical tourniquet deflation including variations in heart rate, respiratory rate and arterial oxygen saturation as well as blood pressure drops. However, RIP may reduce increases in systolic blood pressure and acidosis following tourniquet application.Key Words: Remote Ischemic Preconditioning; Orthopedic, surgery, blood pressure, tourniquet, oxygenation
Keywords
Remote Ischemic Preconditioning Orthopedic surgery blood pressure tourniquet oxygenation
Copyright
© 2016, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.