Preventive Effects of NSAIDs on Lung Tissue Oxidative Damage in an Animal Sepsis Model

How to Cite:Azadeh RasooliMansoureh AbbasiZahra ShaniReza HajihosseiniPreventive Effects of NSAIDs on Lung Tissue Oxidative Damage in an Animal Sepsis Model.J Cell Mol Anesth.7(1):e149696.https://doi.org/10.22037/jcma.v7i1.35259.

Abstract

Background/aim: Sepsis is a very heterogeneous syndrome that is caused by a dysregulated host response to infection. Inflammatory cascades have an important role in sepsis and can potentially be suppressed by anti-inflammatory compounds. So, this study was focused on the antiseptic effects of non-steroidal anti-inflammatory drugs (NSAIDs) on lung injuries based on cecal ligation and puncture (CLP) surgery. Materials and methods: Male wistar rats divided into 6 groups (n=50) as follows: Control, Laparotomy (LAP), CLP and three treatment groups. The rats were killed after 48 h and the lung tissue was subjected to antioxidant enzymes (LP (lipid peroxidation), MPO (myeloperoxidase), and GSH (Glutathione)) and inflammatory genes expression (cyclooxygenase-2 (COX-2), CD177 and MPO). Results: The results indicated that CLP caused lung injury by changes in antioxidant enzymes and genes expression (P<0.05). Treatments with indomethacin, celecoxib and aspirin as anti-inflammatory compounds significantly improved antioxidant enzymes by reducing LP and MPO level as well as genes expression and increasing level of GSH (P<0.05). Conclusion: Our results indicated that sepsis caused oxidative damage in the lung tissue, and the uses of NSAIDs were effective in preventing and improving these injuries.

Keywords

Sepsis

Anti-inflammatory compounds

Antioxidant enzymes

CLP

References

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Author(s):

Azadeh Rasooli:[PubMed][Scholar]
Mansoureh Abbasi:[PubMed][Scholar]
Zahra Shani:[PubMed][Scholar]
Reza Hajihosseini:[PubMed][Scholar]