Abstract
Background/aim: Sepsis is a very heterogeneous syndrome that is caused by a dysregulated host response to infection. Inflammatory cascades have an important role in sepsis and can potentially be suppressed by anti-inflammatory compounds. So, this study was focused on the antiseptic effects of non-steroidal anti-inflammatory drugs (NSAIDs) on lung injuries based on cecal ligation and puncture (CLP) surgery. Materials and methods: Male wistar rats divided into 6 groups (n=50) as follows: Control, Laparotomy (LAP), CLP and three treatment groups. The rats were killed after 48 h and the lung tissue was subjected to antioxidant enzymes (LP (lipid peroxidation), MPO (myeloperoxidase), and GSH (Glutathione)) and inflammatory genes expression (cyclooxygenase-2 (COX-2), CD177 and MPO). Results: The results indicated that CLP caused lung injury by changes in antioxidant enzymes and genes expression (P<0.05). Treatments with indomethacin, celecoxib and aspirin as anti-inflammatory compounds significantly improved antioxidant enzymes by reducing LP and MPO level as well as genes expression and increasing level of GSH (P<0.05). Conclusion: Our results indicated that sepsis caused oxidative damage in the lung tissue, and the uses of NSAIDs were effective in preventing and improving these injuries.
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Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.