A Comparative Study of Effect of Oral Melatonin Versus Oral Midazolam as Premedicant in Children Undergoing Surgery Under General Anesthesia

Ravikanth Pula; Vandana Pakhare; Sunanda Gooty

doi:10.22037/jcma.v7i3.37594

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v7i3.37594

A Comparative Study of Effect of Oral Melatonin Versus Oral Midazolam as Premedicant in Children Undergoing Surgery Under General Anesthesia

Author(s):

Ravikanth Pula¹,

Vandana Pakhare²,

Sunanda Gooty³

1Department of Anesthesiology, ESIC Medical College and Hospital, Sanath Nahar, Hyderabad, India

2ESIC Medical College and Hospital, Sanath Nahar, Hyderabad, India

3HOD & Professor, department of anesthesiology, ESIC medical college and hospital, sanath nahar, Hyderabad, india

Journal of Cellular & Molecular Anesthesia:Vol. 7, issue 3; e149713

Published online:Apr 02, 2022

Article type:Original Articles

How to Cite:Ravikanth PulaVandana PakhareSunanda GootyA Comparative Study of Effect of Oral Melatonin Versus Oral Midazolam as Premedicant in Children Undergoing Surgery Under General Anesthesia.J Cell Mol Anesth.7(3):e149713.https://doi.org/10.22037/jcma.v7i3.37594.

Abstract

Background: Preoperative anxiety in children is associated with multiple post-operative outcomes like post-operative regressive behavioral disturbances, prolonged distress in the recovery phase, eating disorders, and bedwetting. The present study was designed to use low-dose oral melatonin versus oral midazolam in relieving pre-operative anxiety in children in the Indian population. Materials and Methods: A prospective randomized comparative study was conducted on children aged between 2 to 10 years of age scheduled for elective surgeries under general anesthesia are included in the study. This study was conducted with a sample size of 70. Patients were randomly distributed into two groups of 35 content. Group A (received 0.2mg/kg melatonin as premedical) and group B (received 0.5mg/kg midazolam as premedical). Results: Mean induction dose of propofol in the melatonin group was 52.143+ 18.36 mg and in the midazolam, the group was 48.714 + 16.6 mg. In our study, 90 minutes after premedication, the anxiety score was less in the midazolam group. There was no statistically significant difference between the sedation scores in melatonin and midazolam. Conclusion: Low-dose melatonin (0.2mg/kg) is not an effective alternative premedicant in children to alleviate preoperative anxiety compared to midazolam.

Keywords

Melatonin; Midazolam; Pre-operative anxiety; Anesthesia; Propofol

References

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References are in the PDF file of the article.

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Author(s):

Ravikanth Pula:[PubMed][Scholar]
Vandana Pakhare:[PubMed][Scholar]
Sunanda Gooty:[PubMed][Scholar]