Effects of mesenchymal stem cells conditioned medium on behavioral aspects of inflammatory arthritic pain induced by CFA adjuvant

Vida Nazemian; Behzad Nasseri; Homa Manaheji; Jalal Zarringhalam

doi:10.22037/jcma.v1i2.11429

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v1i2.11429

Effects of mesenchymal stem cells conditioned medium on behavioral aspects of inflammatory arthritic pain induced by CFA adjuvant

Author(s):

Vida Nazemian^{1, 2},

Behzad Nasseri^{1, 3},

Homa Manaheji^{1, 3},

Jalal Zarringhalam^{3, 4,*}

1Neurophysiology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Neurophysiology Research Centre & Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 1, issue 2; e149716

Published online:Jul 10, 2016

Article type:Original Articles

How to Cite:Vida NazemianBehzad NasseriHoma ManahejiJalal ZarringhalamEffects of mesenchymal stem cells conditioned medium on behavioral aspects of inflammatory arthritic pain induced by CFA adjuvant.J Cell Mol Anesth.1(2):e149716.https://doi.org/10.22037/jcma.v1i2.11429.

Abstract

Background: Rheumatoid arthritis is a type of inflammatory pain and is an autoimmune and chronic inflammatory disease which can lead to hyperalgesia, edema and decreased motor activity in affected area. Mesenchymal stem cells conditioned medium (MSC-CM) has anti-inflammatory mediators which can regulate the immune responses, alleviate inflammatory symptoms and has a paracrine effects too. The aim of this study was to evaluate the effects of mesenchymal stem cells conditioned medium on behavioral aspects of inflammatory arthritic pain which induced by CFA adjuvant.Materials and Methods: Complete Freund?s adjuvant (CFA)-induced arthritis (AA) was caused by single subcutaneous injection of CFA into the rats hind paw on day zero. MSC-CM was administered daily and intraperitoneal during the 21 days of the study after CFA injection. Hyperalgesia and edema were assessed on days 0, 7, 14 and 21 of the study respectively with radian heat and plethysmometer instrument.Results: The results of this study indicated the significant roles of MSC-CM in betterment of inflammatory symptoms such as hyperalgesia and edema during different stages of inflammation caused by CFA. The continuing injection of MSC-CM could reduce the inflammatory symptoms.Conclusion: Long term treatment by MSC-CM can alleviate hyperalgesia and edema and decrease those to the level of the time before induction of inflammation. ??

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Author(s):

Vida Nazemian:[PubMed][Scholar]
Behzad Nasseri:[PubMed][Scholar]
Homa Manaheji:[PubMed][Scholar]
Jalal Zarringhalam:[PubMed][Scholar]