Potential Neuroprotective Effect of Apis dorsata Honey Against Morphine Tolerance: An in-vivo Study

nur husna zakaria; Nasir Mohamad; Nor Hidayah Abu Bakar; Siti Norhajah Hashim; Halim Shariff; Liyana Hazwani Mohd Adnan

doi:10.22037/jcma.v6i3.35252

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v6i3.35252

Potential Neuroprotective Effect of Apis dorsata Honey Against Morphine Tolerance: An in-vivo Study

Author(s):

nur husna zakaria^1,*,

Nasir Mohamad¹,

Nor Hidayah Abu Bakar¹,

Siti Norhajah Hashim¹,

Halim Shariff²,

Liyana Hazwani Mohd Adnan¹

1Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Kuala Terengganu, Terengganu, Malaysia

2Addiction Interest Group (AIG), International Medical School, Management & Science University (MSU), Shah Alam, Selangor, Malaysia

Journal of Cellular & Molecular Anesthesia:Vol. 6, issue 3; e150190

Published online:Jun 27, 2021

Article type:Original Articles

How to Cite:nur husna zakariaNasir MohamadNor Hidayah Abu BakarSiti Norhajah HashimHalim ShariffLiyana Hazwani Mohd Adnanet al.Potential Neuroprotective Effect of Apis dorsata Honey Against Morphine Tolerance: An in-vivo Study.J Cell Mol Anesth.6(3):e150190.https://doi.org/10.22037/jcma.v6i3.35252.

Abstract

Background: To determine the effects of Apis dorsata honey on the development of morphine tolerance and oxidative stress in rats. Materials and Methods: A total of 40 male Sprague Dawley rats were injected (subcutaneous) with 10 mg/kg of morphine following oral administration of A. dorsata honey (0.5, 1.5, and 2.5g/kg). On day 15, the rats were euthanized, and the thalamus, spinal cord, and hippocampus were homogenized to assess iNOS and MDA using ELISA kits.Results: The honey of A. dorsata significantly prevented morphine tolerance to analgesia in the hotplate test on Day 14 (p<0.05). The biochemical assessment showed that A. dorsata honey significantly reduced MDA formation in the brain regions compared to the morphine control group at dose 2.5g/kg. Elevation of iNOS caused by chronic morphine intake was reduced in A. dorsata honey co-treatment. Conclusion: This study suggests the therapeutic role of A. dorsata honey in preventing morphine tolerance via inhibition of oxidative stress.

Keywords

A. dorsata honey

morphine tolerance

oxidative stress

References

1.
References are in the PDF file of the article.

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Author(s):

nur husna zakaria:[PubMed][Scholar]
Nasir Mohamad:[PubMed][Scholar]
Nor Hidayah Abu Bakar:[PubMed][Scholar]
Siti Norhajah Hashim:[PubMed][Scholar]
Halim Shariff:[PubMed][Scholar]
Liyana Hazwani Mohd Adnan:[PubMed][Scholar]