https://doi.org/10.22037/jcma.v8i1.38295

A Comparative Study of Intravenous Infusion of Ketamine-Propofol and Ketamine-Dexmedetomidine for Deep Sedation and Analgesia in Pediatric Patients Undergoing Day Care Surgeries at Niloufer Hospital

authors:

avatar Lavanya Bachula 1 , * , avatar Gnaneshwari 2 , avatar Seelam Santhosh Kumar 3 , avatar Shiva Putcha 4

Osmania medical college, Hyderabad, India
Department of Anesthesiology Niloufer hospital, Red hills Osmania medical college, Koti Hyderabad
Department of Anesthesiology, Government Medical College, Nalgonda, Telangana, India
Department of Anesthesiology Niloufer hospital, Red hills Osmania medical college, Koti
Journal of Cellular & Molecular Anesthesia: Vol.8, issue 1; e150205
published online: June 12, 2022
article type: Original Articles

How To Cite Bachula L, G, Santhosh Kumar S, Putcha S. A Comparative Study of Intravenous Infusion of Ketamine-Propofol and Ketamine-Dexmedetomidine for Deep Sedation and Analgesia in Pediatric Patients Undergoing Day Care Surgeries at Niloufer Hospital. J Cell Mol Anesth. 2023;8(1):e150205. https://doi.org/10.22037/jcma.v8i1.38295.

Abstract

Background: to compare intravenous infusion of ketamine-propofol and ketamine-dexmedetomidine for deep sedation and analgesia in pediatric patients.Materials and Methods: A total of 60 children aged 3-12 were divided into two groups, to receive drug dosage of Ketamine 2mg/kg and propofol 2 mg/kg IV. In group KP (Ketamine + Propofol) and 2mg/kg ketamine injection; also 1?g/kg dexmedetomidine for group KD (Ketamine + dexmedetomidine). In both groups, hemodynamic changes (MAP, Heart rate, and SpO2), pain, and sedation were assessed intraoperatively at 5, 10, 15, 20, and 30 minutes and post-operatively at 5, 10, 15, 30, and 60 minutes up to 6 hours. Both groups were similar in age distribution and weight from 9-30 Kg. Results: Preoperative heart rate, mean arterial pressure, and SpO2 were statistically insignificant (P>0.05). MAP levels intraoperatively and postoperatively were higher in the KP group. Heart rates were lower in the KD group. Postoperatively pain scores were less in the KD group. Intraoperatively, sedation scores were similar in both groups. Conclusion: the ketamine-propofol group had stable intra and post-operative hemodynamic parameters and early recovery scores.

References

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    References are in the PDF file of the article.