Toll-Like Receptor 4 in Ventilator-Induced Lung Injuries

Bahador Bagheri; Sajad Razavi; Ali Gohari; Sara Salarian; Ali Dabbagh

doi:10.22037/jcma.v1i1.10579

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v1i1.10579

Toll-Like Receptor 4 in Ventilator-Induced Lung Injuries

Author(s):

Bahador Bagheri

¹,

Sajad Razavi²,

Ali Gohari³,

Sara Salarian

^2,*,

Ali Dabbagh

²

1Cancer Research Center and Department of Pharmacology, Semnan University of Medical Sciences, Semnan, Iran

2Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Infectious Diseases, Kowsar Hopsital, Semnan University of Medical Sciences, Semnan, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 1, issue 1; e150239

Published online:Dec 22, 2015

Article type:Review

How to Cite:Bahador BagheriSajad RazaviAli GohariSara SalarianAli DabbaghToll-Like Receptor 4 in Ventilator-Induced Lung Injuries.J Cell Mol Anesth.1(1):e150239.https://doi.org/10.22037/jcma.v1i1.10579.

Abstract

Toll like receptors (TLRs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens. In their bridging role, TLR downstream signals link innate and adaptive immunity, particularly by mediating DC maturation and activation of pathogen specific T lymphocytes. These pathways lead to the activation of professional APCs, which is followed by enhanced expression of surface molecules, MHC and co-stimulatory molecules [CD40, CD80, CD86 and CD70].TLRs are expressed in a variety of cell types, mostly within the immune system where they have been linked to different cellular activation states, immune defense, maintenance of homeostasis, and various diseases. TLRs and related immunological pathways are being extensively studied for research, diagnostic and therapeutic purposes. Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human.?

Keywords

toll-like receptor 4

ventilator

lung injuries

References

1.
References are in the PDF file of the article.

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Author(s):

Bahador Bagheri:[PubMed][Scholar]
Sajad Razavi:[PubMed][Scholar]
Ali Gohari:[PubMed][Scholar]
Sara Salarian:[PubMed][Scholar]
Ali Dabbagh:[PubMed][Scholar]