Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency

authors:

avatar Hedayatollah Elyasi 1 , avatar Akbar Dorgalaleh 2

Department of Hematology and Blood Transfusion, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran
Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
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Journal of Cellular & Molecular Anesthesia: Vol.1, issue 1; e150242
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v1i1.10638

how to cite: Elyasi H, Dorgalaleh A. Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency. J Cell Mol Anesth. 2016;1(1):e150242. https://doi.org/10.22037/jcma.v1i1.10638.

Abstract

Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in the FXIII-A gene with an obvious ethnic difference. This study assessed the prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for the T allele at codon 204 of the FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect. ?