Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency

Majid Naderi; Shadi Tabibian; Shaban Alizade; Zahra Sadat Abtahi; Akbar Dorgalaleh

doi:10.22037/jcma.v1i1.10638

https://doi.org/10.22037/jcma.v1i1.10638

Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency

authors:

Majid Naderi ¹ , Shadi Tabibian ² , Shaban Alizade ² , Zahra Sadat Abtahi ³ , Akbar Dorgalaleh ^{4
, *}

1 Department of Pediatrics Hematology & Oncology, Ali Ebn-e-Abitaleb Hospital Research Center for Children and Adolescents Health [RCCAH], ZahedanUniversity of Medical Sciences, Zahedan, Iran

2 epartmentof Hematologyand Blood Transfusion, Allied Medical School, TehranUniversity of Medical Sciences, Tehran, Iran

3 Departmentof Hematologyand Blood Transfusion, Allied Medical School, TehranUniversity of Medical Sciences, Tehran, Iran

4 Department ofHematology and Blood Transfusion,School of Allied Medical Sciences,Iran University of Medical Sciences,Tehran, Iran.

Journal of Cellular & Molecular Anesthesia: Vol.1, issue 1; e150242

published online: December 22, 2015

article type: Original Articles

How To Cite Naderi M, Tabibian S, Alizade S, Abtahi Z S, Dorgalaleh A. Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency. J Cell Mol Anesth. 2016;1(1):e150242. https://doi.org/10.22037/jcma.v1i1.10638.

Abstract

Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in the FXIII-A gene with an obvious ethnic difference. This study assessed the prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for the T allele at codon 204 of the FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect. ?

Keywords

Coagulation Factor XIII-A A614T gene Congenital Factor XIII Deficiency Factor XIII Polymorphism Mutation

References

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References are in the PDF file of the article.

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Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency

Abstract

Keywords

References

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