Effect of Acid-Base Balance on Cytokines Serum Levels and Short-Term Outcomes in Kidney Transplant Recipients; a Randomized Clinical Trial

authors:

avatar Mohammad Fathi 1 , * , avatar Nilofar Massoudi ORCID 2 , avatar Navid Noori 3 , avatar Narges-Sadat Ghaemi 2 , avatar Davar Amani 4 , avatar Ali Asadirad 5

Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Clinical Research and Development Unit at Shahid Modarres Hospital, Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran
Journal of Cellular & Molecular Anesthesia: Vol.3, issue 1; e150273
published online: January 31, 2018
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v3i1.19537

how to cite: Fathi M, Massoudi N, Noori N, Ghaemi N, Amani D, et al. Effect of Acid-Base Balance on Cytokines Serum Levels and Short-Term Outcomes in Kidney Transplant Recipients; a Randomized Clinical Trial. J Cell Mol Anesth. 2018;3(1):e150273. https://doi.org/10.22037/jcma.v3i1.19537.

Abstract

Background: Control of blood acids and bases can help prevent many potentially life-threatening disorders in end stage renal disease (ESRD) patients. Aim of this study was to assess the effect of acid-base balance on cytokines serum levels and short-term outcomes in kidney transplant recipients.Materials and Methods: In this randomized clinical trial study, 40 patients with end-stage renal disease aged 18 to 70 who had undergone a kidney transplant from a living donor in Modarres hospital during 2016-2017 were included. The primary outcomes measured in this study were sera levels of cytokine such as IL-2, IL-10, IFN-? and BUN and Cr serum after the treatment of acidosis in kidney transplant recipients.Results: Mean?SD of the patient?s age was 42?12.6 years. Results showed that there is a significant difference in means of IL-2, IL-10, and IFN-? between the intervention and control groups over the time (for all p<0.05). We also found that correction of acidosis occurred with reduces of IFN-? to -1.74 in the intervention group compared to the group receiving saline (P=0.011); and reduction for IL-2 was -1.37 (p=0.025). The concentration of anti-inflammatory cytokine of IL-10 was increased to 2.85 (P<0.001).Conclusion: The results clearly suggest that correction of acidosis in renal transplant patients during surgery helps improve the performance of allograft in the short run; however, more studies are recommended, taking into account the long-term and short-term effects of this intervention.Keywords: Cytokines, Kidney Transplantation, Acid-Base Balance, Randomized Controlled Trial

References

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    References are in the PDF file of the article.