The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG

authors:

avatar Kamal Fani ORCID 1 , * , avatar mahdi shadnoush ORCID 2 , avatar alireza jahangirifard 3 , avatar Mahnoosh Foroughi ORCID 4 , avatar Hossein Ali Jelveh Moghaddam 5 , avatar Ali Dabbagh ORCID 6

MD, Assistant Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, PhD, Associate Professor; Department of Clinical Nutrition, Faculty of Nutrition & Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Associate Professor, Fellowship in Cardiac Anesthesia, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Associate Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MD, Assistant Professor, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Professor of Cardiac Anesthesia; Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.3, issue 3; e150279
article type: Original Articles
DOI: https://doi.org/10.22037/jcma.v3i3.19258

how to cite: Fani K, shadnoush M, jahangirifard A, Foroughi M, Jelveh Moghaddam H A, et al. The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG. J Cell Mol Anesth. 2018;3(3):e150279. https://doi.org/10.22037/jcma.v3i3.19258.

Abstract

Introduction: a number of preventive or therapeutic strategies have been proposed to compensate for the inflammatory process during adult cardiac surgeries; none have been considered definitive. 1,25 (OH)2 Vitamin D3 is among the so called physiologic hormones with immunomodulatory effects. This study assessed the effect of oral Vitamin D on serum levels of IL-1, IL-6 and TNF-? in adult CABG.Materials and methods: in a double blind placebo controlled clinical trial, 80 patients entered the study after qualifying study criteria; being divided to Vitamin D and placebo groups, serum cytokines (IL-1, IL-6, and TNF-?) were measured preoperatively and also during the 1st day after the operation.Results: serum TNF-? levels were similar in the 2 groups; however, postoperative levels of IL-1 and IL-6 were significantly lower in Vitamin D group.Conclusion: the current study demonstrated that oral Vitamin D supplements could augment immunomodulatory effects in adult patients undergoing cardiac surgical procedures (mainly CABG).Keywords:?Vitamin D, Cardiopulmonary Bypass, Cytokine, Inflammation