Effect of L-carnitine on Troponin, IL-6 and HS–CRP levels after Coronary Artery Bypass Graft Surgery

authors:

avatar Ali Khalili 1 , avatar Kamal Fani ORCID 2 , avatar Mahdyieh Naziri 3 , avatar Mahnoosh Foroughi 4 , avatar Farzaneh Dastan ORCID 5 , avatar Ali Dabbagh ORCID 2 , avatar Hossein Ali Jelveh Moghaddam 2 , avatar alireza jahangirifard 6 , *

Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cardiac Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Clinical Pharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Chronic Respiratory Diseases Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Journal of Cellular & Molecular Anesthesia: Vol.4, issue 2; e150320
published online: June 20, 2024
article type: Research Article
DOI: https://doi.org/10.5812/jcma-150320

how to cite: Khalili A, Fani K, Naziri M, Foroughi M, Dastan F, et al. Effect of L-carnitine on Troponin, IL-6 and HS–CRP levels after Coronary Artery Bypass Graft Surgery. J Cell Mol Anesth. 2019;4(2):e150320. https://doi.org/10.5812/jcma-150320.

Abstract

Background: L-carnitine seems to be able to prevent complications after heart surgery using Cardiopulmonary bypass (CPB) and the adverse effects of pump usage. This study aimed to evaluates the effects of L-carnitine on cardiac biomarkers and operation characteristics after coronary artery bypass graft (CABG) surgery.Methods and materials: In this randomized triple-blinded, sixty patients undergoing elective CABG surgery were divided into three equal groups to receive 2gr oral L-carnitine (group A), 5gr oral L-carnitine (group B) and placebo (group C) 2 hours before surgery. IL-6, creatinine, and high sensitivity C-reactive protein (HS–CRP) levels, CK-MB, cardiac troponin and inotrope administration in ICU or after CPB were recorded for all patients at baseline levels and at 8 or 24 hours postoperatively.Results: There was an evidence of a significant difference in CPK-MB level and number of red blood cell packed used in group A was lower than group C (p<0.05). The cardiac troponin level 8 hours after surgery significantly decreased in two treatment groups in comparison to group C (p<0.05). The need for inotropic support after weaning from CPB, in B group was statistically higher than C group (p=0.021).Conclusion: Although L-carnitine adjunct therapy appears not to be associated with IL-6 and HS–CRP levels, it had beneficial effects on cardiac troponin and CPK-MB levels.

References

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    References are in the PDF file of the article.