Effect of L-carnitine on Troponin, IL-6 and HS–CRP levels after Coronary Artery Bypass Graft Surgery

Ali Khalili; Kamal Fani; Mahdyieh Naziri; Mahnoosh Foroughi; Farzaneh Dastan; Ali Dabbagh; Hossein Ali Jelveh Moghaddam; alireza jahangirifard

doi:10.5812/jcma-150320

Journal of Cellular & Molecular Anesthesia

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement New Publisher Announcement Reviewer and AE Registration Form Contact Us Support

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/jcma.v4i2.26169

Effect of L-carnitine on Troponin, IL-6 and HS–CRP levels after Coronary Artery Bypass Graft Surgery

Author(s):

Ali Khalili¹,

Kamal Fani

²,

Mahdyieh Naziri³,

Mahnoosh Foroughi⁴,

Farzaneh Dastan

⁵,

Ali Dabbagh

²,

Hossein Ali Jelveh Moghaddam²,

alireza jahangirifard^6,*

1Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Cardiac Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

4Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5Clinical Pharmacy Department, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6Chronic Respiratory Diseases Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 4, issue 2; e150320

Published online:Oct 29, 2019

Article type:Research Article

How to Cite:Ali KhaliliKamal FaniMahdyieh NaziriMahnoosh ForoughiFarzaneh DastanAli DabbaghHossein Ali Jelveh Moghaddamalireza jahangirifardet al.Effect of L-carnitine on Troponin, IL-6 and HS–CRP levels after Coronary Artery Bypass Graft Surgery.J Cell Mol Anesth.4(2):e150320.https://doi.org/10.22037/jcma.v4i2.26169.

Abstract

Background: L-carnitine seems to be able to prevent complications after heart surgery using Cardiopulmonary bypass (CPB) and the adverse effects of pump usage. This study aimed to evaluates the effects of L-carnitine on cardiac biomarkers and operation characteristics after coronary artery bypass graft (CABG) surgery.Methods and materials: In this randomized triple-blinded, sixty patients undergoing elective CABG surgery were divided into three equal groups to receive 2gr oral L-carnitine (group A), 5gr oral L-carnitine (group B) and placebo (group C) 2 hours before surgery. IL-6, creatinine, and high sensitivity C-reactive protein (HS–CRP) levels, CK-MB, cardiac troponin and inotrope administration in ICU or after CPB were recorded for all patients at baseline levels and at 8 or 24 hours postoperatively.Results: There was an evidence of a significant difference in CPK-MB level and number of red blood cell packed used in group A was lower than group C (p<0.05). The cardiac troponin level 8 hours after surgery significantly decreased in two treatment groups in comparison to group C (p<0.05). The need for inotropic support after weaning from CPB, in B group was statistically higher than C group (p=0.021).Conclusion: Although L-carnitine adjunct therapy appears not to be associated with IL-6 and HS–CRP levels, it had beneficial effects on cardiac troponin and CPK-MB levels.

Keywords

Coronary Artery Bypass Graft Surgery

IL-6, HS–CRP levels

L-carnitine

Troponin

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Ali Khalili:[PubMed][Scholar]
Kamal Fani:[PubMed][Scholar]
Mahdyieh Naziri:[PubMed][Scholar]
Mahnoosh Foroughi:[PubMed][Scholar]
Farzaneh Dastan:[PubMed][Scholar]
Ali Dabbagh:[PubMed][Scholar]
Hossein Ali Jelveh Moghaddam:[PubMed][Scholar]
alireza jahangirifard:[PubMed][Scholar]