Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia

Bahram Ghasemzade; Motahare Ghodrati; Naser Kachoeian; Yadollah Banakar; Farhad Gorjipour; Ali Asghar Zarei; Hosein Zaree

doi:10.5812/jcma-151389

Journal of Cellular & Molecular Anesthesia

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement New Publisher Announcement Reviewer and AE Registration Form Contact Us Support

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/jcma.v5i3.30324

Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia

Author(s):

Bahram Ghasemzade¹,

Motahare Ghodrati

^2,*,

Naser Kachoeian³,

Yadollah Banakar⁴,

Farhad Gorjipour⁵,

Ali Asghar Zarei⁶,

Hosein Zaree⁷

1Department of Cardiac Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

2Department of Anesthesiology and Critical Care, Shahid Beheshti Hospital, Qom University of Medical Sciences. Qom, Iran

3Department of Cardiac Surgery, Imam Hussein a.s. Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4MRI Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

5Department of Perfusion, Imam Hussein a.s. Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6Physiology Department, Shiraz University of Medical Sciences, Shiraz, Iran

7Department of Anesthesiology and Critical Care, Shahid Faghihi hospital, Shiraz University of Medical Sciences, Shiraz, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 5, issue 3; e151389

Published online:May 15, 2020

Article type:Research Article

How to Cite:Bahram GhasemzadeMotahare GhodratiNaser KachoeianYadollah BanakarFarhad GorjipourAli Asghar ZareiHosein Zareeet al.Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia.J Cell Mol Anesth.5(3):e151389.https://doi.org/10.22037/jcma.v5i3.30324.

Abstract

Background: Coagulation cascades are activated during Cardiopulmonary Bypass (CPB) and their proper monitoring and maintenance determine the outcomes of operation to a big extent. Here, we assessed serum fibrinogen and Fibrin Degradation Products (FDP) in adult patients undergoing CABG with using CPB, either with hypothermia or normothermia. Materials and Methods: In a cross-sectional study, 80 adult patients’ candidate for elective CABG were randomly assigned into two groups: hypothermia and normothermia to assess fibrinogen and FDP, perioperatively. Results: Patients included 32 men (80%) in the hypothermia group and 26 men (60%) in the normothermia with the mean age of 61.43 ± 12.64 years. The mean temperature in the hypothermia group was 32.33 ± 1.44 and 35.33 ± 0.71 in the normothermic group. Differences in fibrinogen levels between the two groups were not significant (Fib before CPB, P=0.893, and Fib after declamping, P=0.057). The serum level of FDP before and during CPB was not significantly different in hypothermia and normothermia groups (P=0.412, P=0.778, respectively). Conclusion: During cardiac surgery in hypothermia and normothermia conditions rate of fibrinogen decreased 25% after declamping in each group; this decrease seems to be due to hemodilution. FDP levels were similar in both groups.

Keywords

Fibrinogen

fibrin degradation products (FDPs)

Hypothermia

cardiopulmonary bypass

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Bahram Ghasemzade:[PubMed][Scholar]
Motahare Ghodrati:[PubMed][Scholar]
Naser Kachoeian:[PubMed][Scholar]
Yadollah Banakar:[PubMed][Scholar]
Farhad Gorjipour:[PubMed][Scholar]
Ali Asghar Zarei:[PubMed][Scholar]
Hosein Zaree:[PubMed][Scholar]