Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia

authors:

avatar Bahram Ghasemzade 1 , avatar Motahare Ghodrati ORCID 2 , * , avatar Naser Kachoeian 3 , avatar Yadollah Banakar 4 , avatar Farhad Gorjipour 5 , avatar Ali Asghar Zarei 6 , avatar Hosein Zaree 7

Department of Cardiac Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Anesthesiology and Critical Care, Shahid Beheshti Hospital, Qom University of Medical Sciences. Qom, Iran
Department of Cardiac Surgery, Imam Hussein a.s. Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MRI Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Perfusion, Imam Hussein a.s. Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Physiology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Anesthesiology and Critical Care, Shahid Faghihi hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Journal of Cellular & Molecular Anesthesia: Vol.5, issue 3; e151389
published online: May 15, 2020
article type: Research Article
DOI: https://doi.org/10.5812/jcma-151389

how to cite: Ghasemzade B, Ghodrati M, Kachoeian N, Banakar Y, Gorjipour F, et al. Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia. J Cell Mol Anesth. 2020;5(3):e151389. https://doi.org/10.5812/jcma-151389.

Abstract

Background: Coagulation cascades are activated during Cardiopulmonary Bypass (CPB) and their proper monitoring and maintenance determine the outcomes of operation to a big extent. Here, we assessed serum fibrinogen and Fibrin Degradation Products (FDP) in adult patients undergoing CABG with using CPB, either with hypothermia or normothermia. Materials and Methods: In a cross-sectional study, 80 adult patients’ candidate for elective CABG were randomly assigned into two groups: hypothermia and normothermia to assess fibrinogen and FDP, perioperatively. Results: Patients included 32 men (80%) in the hypothermia group and 26 men (60%) in the normothermia with the mean age of 61.43 ± 12.64 years. The mean temperature in the hypothermia group was 32.33 ± 1.44 and 35.33 ± 0.71 in the normothermic group. Differences in fibrinogen levels between the two groups were not significant (Fib before CPB, P=0.893, and Fib after declamping, P=0.057). The serum level of FDP before and during CPB was not significantly different in hypothermia and normothermia groups (P=0.412, P=0.778, respectively). Conclusion: During cardiac surgery in hypothermia and normothermia conditions rate of fibrinogen decreased 25% after declamping in each group; this decrease seems to be due to hemodilution. FDP levels were similar in both groups.

References

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    References are in the PDF file of the article.