Comparison of Two Preoperative Doses of Pregabalin for Attenuation of Postoperative Pain after Laparoscopic Cholecystectomy

2Department of Anaesthesia, Kasturba Medical College, Mangalore, Karnataka, India*Corresponding Author: Sunil VasudevaRao, Associate Professor, Department of Anaesthesia, Kasturba Medical College, Mangalore, Karnataka, India; corresponding authorEmail:drsunilbv@gmail.com

Journal of Cellular & Molecular Anesthesia:Vol. 6, issue 2; e151396

Published online:Apr 17, 2021

Article type:Research Article

How to Cite:Sunil RaoPratibha S SRanjan RamakrishnaComparison of Two Preoperative Doses of Pregabalin for Attenuation of Postoperative Pain after Laparoscopic Cholecystectomy.J Cell Mol Anesth.6(2):e151396.https://doi.org/10.22037/jcma.v6i3.33543.

Abstract

Pregabalin is a novel drug used as an adjunct to multimodal analgesia for reducing post-operative pain. We aimed to compare the efficacy and side effects of two different pre-emptive doses of pregabalin (75 mg vs. 150 mg) for attenuation of postoperative pain following laparoscopic cholecystectomy.
Materials and Methods: This was a prospective randomized study where 70 patients planned for elective laparoscopic cholecystectomy (LC) were enrolled and received a pre-emptive dose of oral pregabalin. Group A received 75 mg and Group B received 150 mg of Pregabalin (PGB) 1 hour before surgery. Assessment of static and dynamic pain was done at 0, 0-4, 4-8, 8-12, 12-16, 16-24 hours post-surgery using Visual Analog Scale (VAS) Score. Adverse effects like postoperative nausea and vomiting (0-6 hr), headache, sedation, and respiratory depression (0-24 hr) were assessed at regular intervals.
Results: There was no significant difference in static and dynamic pain perception at different timed intervals between the two groups. Even the total analgesic requirement in both groups was comparable. The incidence of Postoperative Nausea Vomiting (PONV) (p-value 0.04 ) and headache (P-value 0.034) were statistically significant in Group B when compared to Group A.

Keywords

Pregabalin

Laparoscopic cholecystectomy

Pre-emptive dose

Post-operative pain

References

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Author(s):

Sunil Rao:[PubMed][Scholar]
Pratibha S S:[PubMed][Scholar]
Ranjan Ramakrishna:[PubMed][Scholar]