Uncovering Systemic Lupus Erythematosus Candidate Proteomic Biomarkers: A Bioinformatics Approach

authors:

avatar Mona Zamanian Azodi ORCID 1 , * , avatar Mostafa Rezaei Tavirani 2 , avatar Mohammad Rostami-Nejad ORCID 3 , avatar Babak Arjmand 4 , avatar Mohhamadreza Razzaghi 5

Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti Universityof Medical Sciences, Tehran, Iran
Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

how to cite: Zamanian Azodi M, Rezaei Tavirani M, Rostami-Nejad M, Arjmand B, Razzaghi M. Uncovering Systemic Lupus Erythematosus Candidate Proteomic Biomarkers: A Bioinformatics Approach. J Cell Mol Anesth. 2022;7(1):e151411. https://doi.org/10.5812/jcma-151411.

Abstract

Introduction: Molecular analysis of different types of disease could be helpful to understand the mechanisms of the related abnormal functions at that level of disorder. Lupus is not an exception, by the use of protein-protein interaction network analysis, it is possible to investigate the molecular basis and malfunctions in this kind of disease.
Materials and methods: Thirteen proteins were explored for interaction purposes and some 12 central proteins were obtained via Cytoscape analysis.
Results: Among these proteins, three proteins were from the differentially expressed proteins or in other words reported biomarkers of lupus. These proteins include Haptoglobin (Hp), Apolipoprotein C-III (APOC3), and Apolipoprotein A-I (APOA1).
Discussion: It can be concluded that the biological processes of the central proteins could be part of Lupus's underlying mechanisms. Finally, validation studies are proposed by this current evaluation of the introduced panel of hub biomarkers.

References

  • 1.

    References are in the PDF file of the article.