Uncovering Systemic Lupus Erythematosus Candidate Proteomic Biomarkers: A Bioinformatics Approach

Mona Zamanian Azodi; Mostafa Rezaei Tavirani; Mohammad Rostami-Nejad; Babak Arjmand; Mohhamadreza Razzaghi

doi:10.5812/jcma-151411

Journal of Cellular & Molecular Anesthesia

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement New Publisher Announcement Reviewer and AE Registration Form Contact Us Support

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/jcma.v6i4.34797

Uncovering Systemic Lupus Erythematosus Candidate Proteomic Biomarkers: A Bioinformatics Approach

Author(s):

Mona Zamanian Azodi

^1,*,

Mostafa Rezaei Tavirani²,

Mohammad Rostami-Nejad

³,

Babak Arjmand⁴,

Mohhamadreza Razzaghi⁵

1Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti Universityof Medical Sciences, Tehran, Iran

3Research Institute for Gastroenterology and Liver Diseases, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

5Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 7, issue 1; e151411

Published online:Nov 07, 2021

Article type:Research Article

How to Cite:Mona Zamanian AzodiMostafa Rezaei TaviraniMohammad Rostami-NejadBabak ArjmandMohhamadreza RazzaghiUncovering Systemic Lupus Erythematosus Candidate Proteomic Biomarkers: A Bioinformatics Approach.J Cell Mol Anesth.7(1):e151411.https://doi.org/10.22037/jcma.v6i4.34797.

Abstract

Introduction: Molecular analysis of different types of disease could be helpful to understand the mechanisms of the related abnormal functions at that level of disorder. Lupus is not an exception, by the use of protein-protein interaction network analysis, it is possible to investigate the molecular basis and malfunctions in this kind of disease.

Materials and methods: Thirteen proteins were explored for interaction purposes and some 12 central proteins were obtained via Cytoscape analysis.

Results: Among these proteins, three proteins were from the differentially expressed proteins or in other words reported biomarkers of lupus. These proteins include Haptoglobin (Hp), Apolipoprotein C-III (APOC3), and Apolipoprotein A-I (APOA1).

Discussion: It can be concluded that the biological processes of the central proteins could be part of Lupus's underlying mechanisms. Finally, validation studies are proposed by this current evaluation of the introduced panel of hub biomarkers.

Keywords

Systemic lupus erythematosus

Protein-protein interaction network analysis

Biological process

References

1.
References are in the PDF file of the article.

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

CrossRef 0

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Mona Zamanian Azodi:[PubMed][Scholar]
Mostafa Rezaei Tavirani:[PubMed][Scholar]
Mohammad Rostami-Nejad:[PubMed][Scholar]
Babak Arjmand:[PubMed][Scholar]
Mohhamadreza Razzaghi:[PubMed][Scholar]