Comparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children

How to Cite:Ali Akbar RahbarimaneshHoushang AkhtarharariPeiman SalamatiAfshin shirkaniComparison of Intramuscular Injection of Single-Dose Ceftriaxone and Oral Amoxicillin in Acute Otitis Media in Children.J Compr Ped.1(2):e93742.

Abstract

Background: The present study evaluated efficacy of a single injection of ceftriaxone 50mg/kg IM in comparison with a 10- day treatment course with oral amoxicillin 50mg/kg/d in 3 divided doses for acute otitis media in children. Materials and Methods: A randomized clinical trial was performed on 110 children between 5 months to 12yr who randomly were divided in to ceftriaxone group (n=54) and amoxicillin group (n=56) as case and control groups, respectively. Results: Demographic data and clinical manifestations of patients were similar in both groups. Forty-eight (88.9%) and 51 (91%) patients were cured in case and control groups, respectively. There was no significant different in response to therapy between the two group (p<0.05). Conclusion: This study showed that the efficacy of single injection of ceftriaxone 50mg/kg IM was equal to a 10-day treatment course with oral amoxicillin 50mg/kg/d divided in 3 doses in non-complicated acute otitis media in children.

Keywords

ceftriaxone

Amoxicillin

Acute otitis media

References

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