Cytomegalovirus, a Common Cause of Intrauterine Infection: A Case - Control Study in Tehran, Iran

samileh noorbakhsh; Mohammad Farhadi; Azardokht Tabatabaei

Journal of Comprehensive Pediatrics

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Cytomegalovirus, a Common Cause of Intrauterine Infection: A Case - Control Study in Tehran, Iran

Author(s):

samileh noorbakhsh^1,*,

Mohammad Farhadi²,

Azardokht Tabatabaei¹

1Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

2Research Center for Diseases of Ear, Nose and Throat, Iran University of Medical Sciences, Tehran, Iran

Journal of Comprehensive Pediatrics:Vol. 2, issue 1; e93759

Published online:Jun 30, 2010

Article type:Research Article

Received:May 15, 2019

Accepted:Jun 30, 2010

How to Cite:samileh noorbakhshMohammad FarhadiAzardokht TabatabaeiCytomegalovirus, a Common Cause of Intrauterine Infection: A Case - Control Study in Tehran, Iran.J Compr Ped.2(1):e93759.

Abstract

Background and Aim: Congenital cytomegalovirus (CMV) infection affects~1% of live births in the United States. Ten percent of these infants have symptoms at birth and another 10 to 15% develop hearing loss or developmental problems.The aim of this study was to compare CMV infection (IgM and IgG) in infants suspected for intrauterine infection with the controls.
Materials and Methods: A case control study was performed in the Pediatrics department of Hazrat Rasool Akram Hospital in Tehran (2002-2003). We compared the serum CMV antibodies (IgM &IgG-ELISA) of 74 cases suspected of intrauterine infection (mean age =4.7r3.7 months) with that of 65 controls (mean age=5.3r3.1 months).
Results: Acute and previous immunity to CMV (IgM and IgG ) was found in 41.9% (31/74) and 74% (54/74) of the cases, respectively. Meanwhile acute infection (IgM) was observed in 6.2% (4/65) and previous immunity (IgG) in 95.4% (62/65) of the controls. Acute infection (CMV-IgM) was higher in cases (p-value=0.000), but previous immunity (CMV-IgG) was higher in the controls (p value=0.001).
Conclusion: We conclude that like other countries, CMV is the most common cause of intrauterine infection in infants aged less than 6 months as compared to the healthy ones.We prefer, at least in our country, to consider seropositive (CMV-IgM) infants suspected of intrauterine infection (less than 6 months) as congenital form.To arrest the natural progression of congenital CMV, we recommend prolonged course of oral analogues of ganciclovir for children with symptomatic congenital CMV.

Keywords

Congenital cytomegalovirus

Cytomegalovirus (CMV)

Ganciclovir

Sensorineural Hearing Loss (SNHL)

References

1.
The references are available in PDF file.

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