Infectious Causes and Associated Factors of Mortality in Pediatric Patients: Letter to Editor


avatar Soraya Siabani 1 , avatar Maryam Babakhani ORCID 2 , * , avatar Ali Soroush ORCID 2

Faculty of Health, University of Technology Sydney, Sydney, Australia
Kermanshah University of Medical Sciences, Kermanshah, Iran

how to cite: Siabani S, Babakhani M, Soroush A. Infectious Causes and Associated Factors of Mortality in Pediatric Patients: Letter to Editor. J Compr Ped.11(2):e97198. doi: 10.5812/compreped.97198.

Dear Editor,

Although millennium development goal 4 (MDG4) calls for an end to preventable child deaths, child mortality remains a problem in many nations, and millions of children are still dying due to preventable causes (1, 2). Likewise, analyzing child mortality, as a basic indicator of health and development of countries, can help health policymakers, health caregivers, and researchers to prioritize funding, improve interventional activities, revise medical services, and increase survival (3). On the other hand, based on evidence, infectious diseases are the most important causes of death in children, especially younger than five-year-old children (4, 5). Therefore, the current study was conducted to explore deaths caused by infectious and parasitic diseases and predicting factors among patients ≤ 18 years admitted to Imam Reza Hospital (IRH) for five years from 2011 to 2016.

The study setting was Imam Reza Hospital (IRH), located in the north of Kermanshah City. In this retrospective descriptive-analytical study, all deaths caused by infectious and parasitic diseases were explored for data related to the study objectives for five years from April 2011 to March 2016. The inclusion criteria were the age of ≤ 18 years and adequate information. The cases with incomplete personal or medical information and deaths before medical services in IRH were excluded.

Data were collected by two nurses who well trained for data gathering using an open-ended questionnaire developed based on the study objectives. The questionnaire was evaluated and approved based on expert opinions comprising a statistician and an internal specialist medical doctor. Demographic characteristics (e.g., age and sex), medical histories (e.g., admitted ward), and the cause of death were collected.

Data analysis was performed using Statistical Package for Social Sciences (SPSS) software (version 22.0; IBM Corporation, Chicago, USA). Qualitative/categorical variables were expressed as frequencies and percentages. The chi-square test was used to assess any association between the causes of death and explanatory factors such as age, gender, and comorbidity. A probability value (P value) of less than 0.05 was considered statistically significant.

The Research Ethics Committee of Kermanshah University of Medical Sciences (KUMS) approved the study protocol (ethics registration no.: 96366). Furthermore, general and individual information was kept confidential.

The total number of recorded deaths was 1,113 between 2011 and 2016. The most frequent causes of in-hospital child mortality were respiratory system diseases (34%), infectious diseases (28.8), diseases of the blood (13%), diseases of the circulatory system (5.6%), congenital malformations (4.2%), trauma (2.9%), and neoplasms (1.3%). Indeed, 321 deaths (28.8% of the total) were caused by infectious and parasitic diseases. These results are consistent with the findings by Sankaran et al. (6) and Lawn et al. (7), who showed that infectious and parasitic diseases were the leading causes of child mortality. Infectious and parasitic diseases being on the top of mortality causes are concerning and necessitates serious attention. Most deaths were among neonates (75.7%) and females (53.9%). This is in line with the results of previous studies. Similarly, Rabbani et al. (8) and Liu et al. (9) showed that child mortality mostly occurred in the neonatal period. Nowadays, child mortality is shifting to the time of birth; thus, we need advances in perinatal and neonatal care to reduce neonatal mortality rates.

About 96.0% of cases were suffering from at least one comorbidity. Preterm birth and hyaline membrane disease (HMD) were the most common comorbidities, accounting for 34.7% and 18.2% of cases, respectively. The most frequently occupied hospital wards by participants were neonatal ICU (74.1%) and pediatric ICU (20.2%). Similarly, previous publications reported significant mortality rates in NICUs (6, 10). About 91.9% of the cases had been supported by health insurance (Table 1).

Table 1. Baseline Characteristics of Children (N = 321)a
Neonates, ≤ 1 month243 (75.7)
Infants, ≤ 12 months31 (9.7)
Toddlers and pre-school children, 1 - 5 years26 (8.1)
School-aged children, 6 - 12 years8 (2.5)
Teenagers, 13 - 18 years13 (4.0)
Male148 (46.1)
Female173 (53.9)
Health insurance
Yes295 (91.9)
Yes308 (96.0)
Admitting ward
Neonatal ICU238 (74.1)
Pediatric ICU65 (20.2)
Pediatric ward8 (2.5)
Operating room8 (2.5)
Infectious causes of mortality
Sepsis262 (82.2)
Septic shock40 (12.5)
Pneumonia11 (3.4)
Cerebral toxoplasmosis infection6 (1.8)

The study demonstrated that the most frequent causes of in-hospital child mortality were sepsis (82.2%) and septic shock (12.5%). Previous studies conducted by Liu et al. (4) and Alijani Ranani et al. (11) showed that sepsis was the most common cause of pediatric deaths. Age was significantly associated with the causes of death (P value = 0.001). Deaths due to sepsis and septic shock were more common in neonates, while pneumonia was the main cause of death in toddlers and pre-school children.

A major limitation of this study was the poor documentation of medical information. To face this limitation, we obtained the data from both paperwork records and electronic medical records. In addition, the lack of detailed patients’ information made it difficult to assess the associated factors.



  • 1.

    Wang H, Bhutta ZA, Coates MM, Coggeshall M, Dandona L, Diallo K, et al. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016;388(10053):1725-74. doi: 10.1016/S0140-6736(16)31012-1.

  • 2.

    Bryce J, Black RE, Victora CG. Millennium Development Goals 4 and 5: progress and challenges. BMC medicine. 2013;11(1):225. [PubMed: 24228742].

  • 3.

    World Health Organization. Death reviews: Maternal, perinatal and child. Geneva: WHO; 2013.

  • 4.

    Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. The Lancet. 2012;379(9832):2151-61. doi: 10.1016/S0140-6736(12)60560-1.

  • 5.

    Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. The lancet. 2010;375(9730):1969-87. doi: 10.1016/S0140-6736(10)60549-1.

  • 6.

    Sankaran K, Chien L, Walker R, Seshia M, Ohlsson A, Lee SK. Variations in mortality rates among Canadian neonatal intensive care units. Canadian Medical Association Journal. 2002;166(2):173-8.

  • 7.

    Lawn JE, Wilczynska-Ketende K, Cousens SN. Estimating the causes of 4 million neonatal deaths in the year 2000. International journal of epidemiology. 2006;35(3):706-18. [PubMed: 16556647].

  • 8.

    Rabbani S, Qayyum A. Comparative analysis of factor affecting child mortality in Pakistan. Res J Soc Sci. 2017.

  • 9.

    Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. The Lancet. 2015;385(9966):430-40. doi: 10.1016/S0140-6736(14)61698-6.

  • 10.

    Lee SK, McMillan DD, Ohlsson A, Pendray M, Synnes A, Whyte R, et al. Variations in practice and outcomes in the Canadian NICU network: 1996–1997. Pediatrics. 2000;106(5):1070-9. [PubMed: 11061777].

  • 11.

    Alijani Ranani H, Madhoshi S, Moghimzadeh F. Evaluation of the cause and predisposing factors in neonatal mortality based on international coding disease version10 in Aboozar Hospital of Ahvaz. Yafte. 2017;19(1).

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