Coagulation and Angiogenesis in Cancer-Review Article

Kamran  Mansouri; Farhad  Oubari; Somayeh  Shamllo; Parya  Ahmadi; Mahboob  Kashani

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Coagulation and Angiogenesis in Cancer-Review Article

Author(s):

Kamran Mansouri^1,*,

Farhad Oubari¹,

Somayeh Shamllo¹,

Parya Ahmadi¹,

Mahboob Kashani²

1Medical Biology Research Center, Kermanshah University of Medical Sciences , Kermanshah, Iran

2Department of Laboratory Sciences , Faculty of Paramedics, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 5, issue 2; e81465

Published online:Jun 13, 2016

Article type:Review Article

Received:Oct 16, 2015

Accepted:Apr 20, 2016

How to Cite: Mansouri K, Oubari F, Shamllo S, Ahmadi P, Kashani M, Coagulation and Angiogenesis in Cancer-Review Article.J Clin Res Paramed Sci.2016;5(2):e81465.

Abstract

Introduction: Angiogenesis, is involved in development, wound healing and pathological conditions such as tumor growth.Both hemostatic and angiogenic systems are applied to stop bleeding .They were activated through being exposed to subendothelial matrix. Any disturbance in hemostatic and angiogenic system lead to tumor growth and metastasis.

Methods: At first related articles about angiogenesis and coagulation systems, The due systems were searched from valid databases such as WILY ONLINE LIBRARY, ISI web of science, Springer Link, Sciencedirect, Pubmed, google scholar, SID and ISC. Then, the related articles were studied from 2002 to 2014.

Results: In normal condition,angiogenesis occurs through the establishment of balance among proangiogenic , anti-angiogenic,coagulation and anticoagulation factors. These factors and agents support angiogenic system and result consequently in tumor growth ,metastasis and the increase of susceptible patient to coagulopathy.

Conclusion: : The tight regulatory balance between pro- and antiangiogenic factors is disturbed in favor of angiogenic stimulators which lead to cancer development. Coagulation is synergistically activated, so the patient develops the increased risk of a thrombotic event. In addition to their recognized role to regulate coagulation, platelet-derived hemostatic and plasma factors also contribute to the regulation of angiogenesis. Because tumor growth and metastasis depend on angiogenesis, negative regulators angiogenesis have special interest as potential anti-angiogenesis and anti-cancer agents.

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