The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells

Samira  Rasaneh; Saleh  Salehi Zahabi

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells

Author(s):

Samira Rasaneh^1,*,

Saleh Salehi Zahabi²

1Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

2Department of Radiology and Nuclear Medicine, Paramedicine School, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 4, issue 4; e82069

Published online:Jan 05, 2016

Article type:Research Article

Received:Jun 04, 2015

Accepted:Nov 06, 2015

How to Cite:Samira RasanehSaleh Salehi ZahabiThe effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells.J Clin Res Paramed Sci.4(4):e82069.

Abstract

Background: Paclitaxel is a new chemotherapy medicine that is used for treating breast, ovarian, and lung cancers as well as AIDS-related Kaposi's sarcoma. Due to the side effects of using this drug, the paclitaxel-loaded chitosan nanoparticles was synthesized and its cytotoxicity effects on breast cancer cell lines was examined.

Methods: The paclitaxel-loaded chitosan nanoparticles were synthesized by the gelation method, purified and isolated in a proper size by centrifugation. The nanoparticles’ size, percentage of loading and releasing time of the drug up to 24 hours and its cytotoxicity effects, compared with Paclitaxel; on breast cancer cell lines were investigated.

Results: Particle sizes revealed to be 248-312 nm using the zetasizer system, the drug loading percentage showed 55±4 %, and the rate of drug releasing time for 24 h measured 5.5 %. On the average in concentration of 0.8 μg/mL the cytotoxicity of the paclitaxol-loaded chitosan nanoparticles was estimated 43% less than that of the taxol.

Conclusion: The results showed that the paclitaxol-loaded chitosan nanoparticles may be considered as a good alternative to taxol since it decreases the related side effects. However, it deserves further investigations in future.

Keywords

Paclitaxol

Chitosan nanoparticles

Drug delivery

Breast cancer

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