The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells

authors:

avatar Samira Rasaneh 1 , * , avatar Saleh Salehi Zahabi 2

Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
Department of Radiology and Nuclear Medicine, Paramedicine School, Kermanshah University of Medical Sciences, Kermanshah, Iran
Journal of Clinical Research in Paramedical Sciences: Vol.4, issue 4; e82069
published online: January 05, 2016
article type: Research Article
received: June 04, 2015
accepted: November 06, 2015

how to cite: Rasaneh S, Salehi Zahabi S . The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells. J Clin Res Paramed Sci. 2016;4(4):e82069. 

Abstract

Background: Paclitaxel is a new chemotherapy medicine that is used for treating breast, ovarian, and lung cancers as well as AIDS-related Kaposi's sarcoma. Due to the side effects of using this drug, the paclitaxel-loaded chitosan nanoparticles was synthesized and its cytotoxicity effects on breast cancer cell lines was examined.
Methods: The paclitaxel-loaded chitosan nanoparticles were synthesized by the gelation method, purified and isolated in a proper size by centrifugation. The nanoparticles’ size, percentage of loading and releasing time of the drug up to 24 hours and its cytotoxicity effects, compared with Paclitaxel; on breast cancer cell lines were investigated.
Results: Particle sizes revealed to be 248-312 nm using the zetasizer system, the drug loading percentage showed 55±4 %, and the rate of drug releasing time for 24 h measured 5.5 %. On the average in concentration of 0.8 μg/mL the cytotoxicity of the paclitaxol-loaded chitosan nanoparticles was estimated 43% less than that of the taxol.
Conclusion: The results showed that the paclitaxol-loaded chitosan nanoparticles may be considered as a good alternative to taxol since it decreases the related side effects. However, it deserves further investigations in future.

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