The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells

authors:

avatar Samira Rasaneh 1 , * , avatar Saleh Salehi Zahabi 2

Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
Department of Radiology and Nuclear Medicine, Paramedicine School, Kermanshah University of Medical Sciences, Kermanshah, Iran

how to cite: Rasaneh S, Salehi Zahabi S . The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells. J Clin Res Paramed Sci. 2016;4(4):e82069. 

Abstract

Background: Paclitaxel is a new chemotherapy medicine that is used for treating breast, ovarian, and lung cancers as well as AIDS-related Kaposi's sarcoma. Due to the side effects of using this drug, the paclitaxel-loaded chitosan nanoparticles was synthesized and its cytotoxicity effects on breast cancer cell lines was examined.
Methods: The paclitaxel-loaded chitosan nanoparticles were synthesized by the gelation method, purified and isolated in a proper size by centrifugation. The nanoparticles’ size, percentage of loading and releasing time of the drug up to 24 hours and its cytotoxicity effects, compared with Paclitaxel; on breast cancer cell lines were investigated.
Results: Particle sizes revealed to be 248-312 nm using the zetasizer system, the drug loading percentage showed 55±4 %, and the rate of drug releasing time for 24 h measured 5.5 %. On the average in concentration of 0.8 μg/mL the cytotoxicity of the paclitaxol-loaded chitosan nanoparticles was estimated 43% less than that of the taxol.
Conclusion: The results showed that the paclitaxol-loaded chitosan nanoparticles may be considered as a good alternative to taxol since it decreases the related side effects. However, it deserves further investigations in future.

Fulltext

The full text of this article is available on PDF.

References

  • 1.

    The References of this article is available on PDF.