Multidrug resistance in Pseudomonas aeruginosa and  Enterobacter cloacae isolated from intensive care units of Qazvin  and Tehran hospitals

Amir  Peymani; Moein‏  ‏Yeylagh Beigi; Mahdi‏ ‏‎ ‏ Mohammadi Ghanbarlou‎; Reza  Najafipour; Rasoul‏  ‏Samimi ‎

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Multidrug resistance in Pseudomonas aeruginosa and Enterobacter cloacae isolated from intensive care units of Qazvin and Tehran hospitals

Author(s):

Amir Peymani¹,

Moein‏ ‏Yeylagh Beigi²,

Mahdi‏ ‏‎ ‏ Mohammadi Ghanbarlou‎²,

Reza Najafipour¹,

Rasoul‏ ‏Samimi ‎^3,*

1Cellular and Molecular‏ ‏Research Center, Qazvin‏ ‏University of Medical‏ ‏Sciences, Qazvin‎, Iran

2Department of Medical‏ ‏Microbiology, Qazvin‏ ‏University of Medical‏ ‏Sciences, Qazvin‎, Iran

3Department of Internal‏ ‏Medicine, School of Medicine,‎‏ ‏Qazvin University of Medical‏ ‏Sciences, Qazvin‎, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 3, issue 1; e82084

Published online:May 14, 2014

Article type:Research Article

Received:Oct 10, 2013

Accepted:Mar 19, 2014

How to Cite:Amir PeymaniMoein‏ ‏Yeylagh BeigiMahdi‏ ‏‎ ‏ Mohammadi Ghanbarlou‎Reza NajafipourRasoul‏ ‏Samimi ‎Multidrug resistance in Pseudomonas aeruginosa and Enterobacter cloacae isolated from intensive care units of Qazvin and Tehran hospitals.J Clin Res Paramed Sci.2014;3(1):e82084.

Abstract

Introduction: Pseudomonas aeruginosa and Enterobacter cloacae are the most common organisms involved in clinical disease among patients admitted in ICUs. The treatment of these infections is often difficult due to several virulence factors and drug resistance
mechanisms. The aim of this study was to evaluate multidrugresistance pattern among clinical P. aeruginosa and E. cloacae isolates collected from ICUs.
Methods: In total, 82 and 49 P. aeruginosa and E. cloacae isolates were collected from ICUs of Tehran and Qazvin hospitals. The species identification was performed by standard laboratory methods. Antimicrobial susceptibility and multidrug resistance (MDR) pattern
were further evaluated by Kirby-Baure method according to CLSI guideline.
Results: In this study, the highest resistance rate was shown to cefpodoxime (98.8%) and cefotaxime (97.6%) in P. aeruginosa and to amoxicillin-clavulanic (98%) acid and ampicillin (95.9%) in E. cloacae isolates. Twenty six (53.1%) E. cloacae and 43 (52.4%) P. aeruginosa isolates showed the multidrug resistance pattern.
Conclusion: The present study showed the considerable frequency of MDR pattern among P. aeruginosa and E. cloacae isolates collected from studied hospitals. Therefore, there is need for efficient infection control and appropriate therapeutic practices, especially in ICUs.

Keywords

Enterobacter cloacae

Pseudomonas aeruginosa

MDR

IC

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