Abstract
mechanisms. The aim of this study was to evaluate multidrugresistance pattern among clinical P. aeruginosa and E. cloacae isolates collected from ICUs.
Methods: In total, 82 and 49 P. aeruginosa and E. cloacae isolates were collected from ICUs of Tehran and Qazvin hospitals. The species identification was performed by standard laboratory methods. Antimicrobial susceptibility and multidrug resistance (MDR) pattern
were further evaluated by Kirby-Baure method according to CLSI guideline.
Results: In this study, the highest resistance rate was shown to cefpodoxime (98.8%) and cefotaxime (97.6%) in P. aeruginosa and to amoxicillin-clavulanic (98%) acid and ampicillin (95.9%) in E. cloacae isolates. Twenty six (53.1%) E. cloacae and 43 (52.4%) P. aeruginosa isolates showed the multidrug resistance pattern.
Conclusion: The present study showed the considerable frequency of MDR pattern among P. aeruginosa and E. cloacae isolates collected from studied hospitals. Therefore, there is need for efficient infection control and appropriate therapeutic practices, especially in ICUs.
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