Evaluation of single dose Pregabalin vs. placebo in reducing post–  Photorefractive Keratectomy pain

Mansour  Chubsaz; Farid  Daneshgar; Nasrin  Amiri Fard‎; Tayebeh  Kazerooni‎; Ebrahim  Ghaderi‎

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Evaluation of single dose Pregabalin vs. placebo in reducing post– Photorefractive Keratectomy pain

Author(s):

Mansour Chubsaz¹,

Farid Daneshgar²,

Nasrin Amiri Fard‎^3,*,

Tayebeh Kazerooni‎¹,

Ebrahim Ghaderi‎⁴

1Department of Anesthesiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

2Department of Ophthalmology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

3Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

4Eye Research Center, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 3, issue 3; e82116

Published online:Oct 13, 2014

Article type:Research Article

Received:Mar 09, 2014

Accepted:Aug 14, 2014

How to Cite:Mansour ChubsazFarid DaneshgarNasrin Amiri Fard‎Tayebeh Kazerooni‎Ebrahim Ghaderi‎Evaluation of single dose Pregabalin vs. placebo in reducing post– Photorefractive Keratectomy pain.J Clin Res Paramed Sci.3(3):e82116.

Abstract

Background: Today, Photorefractive keratectomy (PRK) is one of the most common methods of eye surgery and the most important problem of patient and medical team that are confronted about this surgery is pain. The aim of this study was to determine the
efficacy of Pregabalin for reducing post–photorefractive keratectomy (PRK) pain.
Methods: This study was done as a double blind clinical trial. Patients were divided in two groups (40 patients in each group) as case and control and 30 minute before surgery 150 mg Pregabalin and placebo were prescribed for case and control groups, respectively. In 6, 12 and 24 hours after surgery, pain was measured by Visual Analog Scale (VAS).
Results: The results of this study were showed pain score in 6 and 12 hours after surgery in Pregabalin group was significant lower than control (P<0.001). In Pregabalin group, after 6 hours, 17 patients (42.5%) had VAS score >3 and needs to Acetaminophen;
whereas in control group 33 patients (82.5%) had VAS score >3 (P<0.001). Further, there wasn't any side effect in Pregabalin group.
Conclusion: Our study showed Pregabalin is an effective and with low side effect medicine for reducing of post–photorefractive keratectomy pain.

Keywords

Photorefractive keratectomy

Pregabalin

pain

Visual Analog Scale

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