Presence of alginate among multidrug resistant Pseudomonas  aeruginosa isolated from clinical samples in Qazvin and Tehran  hospitals

Narges  Pourzereshki; Taghi‏ ‏ Naserpour Farivar; Amir‏ ‏ Peymani‎

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Presence of alginate among multidrug resistant Pseudomonas aeruginosa isolated from clinical samples in Qazvin and Tehran hospitals

Author(s):

Narges Pourzereshki¹,

Taghi‏ ‏ Naserpour Farivar²,

Amir‏ ‏ Peymani‎^2,*

1The Islamic Azad UniversityZanjan Branch, Zanjan‎, Iran

2Cellular and Molecular‏ ‏Research Center, Qazvin‏ ‏University of Medical Sciences, Qazvin‎, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 3, issue 4; e82128

Published online:Feb 20, 2015

Article type:Research Article

Received:Jul 19, 2014

Accepted:Jan 20, 2015

How to Cite:Pourzereshki N, Naserpour Farivar T ‏, Peymani‎ A ‏, Presence of alginate among multidrug resistant Pseudomonas aeruginosa isolated from clinical samples in Qazvin and Tehran hospitals.J Clin Res Paramed Sci.2015;3(4):e82128.

Abstract

Background: Pseudomonas aeruginosa is an opportunistic infection that can occur in burn and immunocompromised patients causing several clinical problems for specialists. Most of
infection caused by this organism are associated with production of alginate exopolysaccharide and biofilm formation in targets which can increase drug resistance. The aim of this study was to evaluate the frequency of alginate among multidrug resistant P.
aeruginosa isolated from Qazvin and Tehran hospitals.
Methods: In total, 115 clinical P. aeruginosa isolates were collected from educational hospitals of Qazvin and Tehran hospitals during 2012 to 2014. Antimicrobial susceptibility was further determined by disk agar diffusion method. PCR and sequencing assays were performed for detection of algD gene among MDR isolates.
Results: Results of this study showed 94(81.7%) of MDR isolates were positive for the presence of algD gene. The positive isolates were mostly obtained from blood samples (28.7%) and patients admitted in ICUs (36.5%).
Conclusion: These findings showed the high prevalence of algD among MDR P. aeruginosa isolated from admitted patients in studied hospitals. According to clinical importance of these isolates, using an appropriate infection control policy and therapeutic strategy is necessary

Keywords

Pseudomonas aeruginosa

Multidrug resistance

Alginate

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