Survey of serum levels of brain-derived neurotrophic factor in  autistic rats

Maryam  Soori; Mohammad‏ ‏Amin  Edalatmanesh‎

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Survey of serum levels of brain-derived neurotrophic factor in autistic rats

Author(s):

Maryam Soori¹,

Mohammad‏ ‏Amin Edalatmanesh‎^1,*

1Department of Physiology,‎‏ ‏College of Sciences, Shiraz‏ ‏Branch, Islamic Azad University, Shiraz‎, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 3, issue 4; e82129

Published online:Feb 22, 2015

Article type:Research Article

Received:Jul 20, 2014

Accepted:Jan 22, 2015

How to Cite:Soori M, Edalatmanesh‎ M ‏, Survey of serum levels of brain-derived neurotrophic factor in autistic rats.J Clin Res Paramed Sci.2015;3(4):e82129.

Abstract

Background: Autism syndrome is a complex neurological disorder. The main causes of autism disorder is not fully understood. However, the results of some studies indicated that
change in serum level of brain-derived neurotrophic factor (BDNF) has role in autism etiology but, amount and how to change of this factor in not clear today. The aim of this study was to determine the serum levels of BDNF and its relation with repetitive behaviors test in autistic newborn rats.
Methods: In this study we used 15 virgin female rats that divided into 2 case and control groups; for inducing of autism in their newborns, they exposed to Valporic acid on 12.5 of pregnancy. For measuring serum levels of BDNF and evaluation of repetitive behaviors, we used elisa method and Maze Y test, respectively.
Results: The results of this study indicated that in autistic rats, median of BDNF serum levels is significantly increase in compare to the control group (P<0.001). Also, in female rats, serum levels of BDNF is significantly higher than male rats (P<0.01). There wasn’t significant relation between serum levels of BDNF and repetitive behaviors (P=0.23).
Conclusion: In summary, we concluded that serum levels of BDNF has change in autism syndrome and it can has role in etiology of this disorder. However, according to conflicting results of studies about serum levels of BDNF and it relation with severity of this disorder, more research recommended.

Keywords

Autism syndrome

brain-derived neurotrophic factor

Maze Y

serum level

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