Effects of Curcumin on Reproductive Parameters in Male Mice

Mohammad Reza Salahshoor; Cyrus  Jalili; Mozafar  Khazaei; Fuzie  Khani

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Effects of Curcumin on Reproductive Parameters in Male Mice

Author(s):

Mohammad Reza Salahshoor¹,

Cyrus Jalili^1,*,

Mozafar Khazaei¹,

Fuzie Khani²

1Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 1, issue 3; e82189

Published online:Oct 09, 2012

Article type:Research Article

Received:Mar 15, 2012

Accepted:Aug 20, 2012

How to Cite:Salahshoor M R, Jalili C, Khazaei M, Khani F, Effects of Curcumin on Reproductive Parameters in Male Mice.J Clin Res Paramed Sci.2012;1(3):e82189.

Abstract

Backgrand: Infertility is a health problem that causes adverse effects in personal, social and
economic domains. Infertility in males has been associated with sperm dysfunctions such as low
sperm count, immaturity, abnormality and lack of motilty. The color of turmeric is because of a
substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been
identified. Although researchers have reported the anti-oxidant properties of curcumin, its effects on
reproductive hormones, epididymis pathway, and sperm count and motility in nicotine-infected rats
have not been investigated.
Methodes In this study, various doses of curcumin (10, 30 and 60 mg/kg) were administered intraperitoneally to male mice for 28 consequent days and reproductive parameters as testosterone
hormone, motility, morphology, testis weight and histology were analyzed and compared.
Results: The results indicated that increasing the dose of curcumin significantly increased
reproductive indices such as sperm count, motility, testis weight and testosterone hormone in most
of the groups (P≤05).
Conclusions: It seems that curcumin increase the quality and quantity of reproductive indices in
male mice.

Keywords

Curcumin

reproductive parameters

Male mice

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References

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