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Addictive effects of nicotine on rat cerebral cortex


avatar Cyrus Jalili ‎ 1 , avatar Zahra Jalili‎ 2 , avatar Froozan Khademi ‎ 3 , avatar Dariyush Pourmand‎ 4 , avatar Mohammad Reza‏ ‏ Salahshoor ‎ 1 , *

1 Fertility and Infertility Research‏ ‏Center, Kermanshah University of‏ ‏Medical Sciences, ‎Kermanshah‎, Iran

2 Department of Pediatric Cardiology,‎‏ ‏Imam Ali Heart Center, Kermanshah‏ ‏University of‏ ‏Medical Sciences,‎‏ ‏Kermanshah‎, Iran

3 School of Medicine, Kermanshah‏ ‏University of Medical Sciences,‎‏ ‏Kermanshah‎, Iran

4 Department of Medical‏ ‏Laboratory Sciences, School of‏ ‏Paramedicine, Kermanshah‏ ‏University of Medical Sciences,‎‏ ‏Kermanshah‎, Iran

How to Cite: Jalili ‎ C , Jalili‎ Z, Khademi ‎ F , Pourmand‎ D , Salahshoor ‎ M R ‏. Addictive effects of nicotine on rat cerebral cortex. J Clin Res Paramed Sci. 2013;2(1):e82203.


Journal of Clinical Research in Paramedical Sciences: 2 (1); e82203
Published Online: May 15, 2013
Article Type: Research Article
Received: September 16, 2012
Accepted: March 15, 2013


Introduction: The most important alkaloid compound in tobacco is nicotine. Around 30% of the people in different countries are addicted to nicotine. Nicotine is also the leading cause of smoking. Prefrontal is part of the cerebral cortex that plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is
located in mesocorticolimbic dopamine system. However, with regard to the significant role of prefrontal cortex, no study has been conducted on the effects of nicotine on
morphological changes in prefrontal cortex region, so far. Thus, we purpose to investigate the addictive effects of nicotine on rat cerebral cortex.
Methods: Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their
brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. The data were analyzed using SPSS software.
Results: By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose, nicotine caused a significant decrease and increase in the size of pericarions and dendritic spines, respectively (P<0.05).
Conclusion: Nicotine administration can decrease the size of pericarion and number of dendritic spines in the prefrontal cortex.


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