Frequency ofantibodies againstbloodgroup antigens in patient ofGhaem hospitalMashhad

Mohammad Hadi  Sadeghian; Seyede Fateme  Shams; Toktam  Saneie; Seyed Masoud   Alavi; Ahmad  Ashjaee; Mohsen  Dashti

Journal of Clinical Research in Paramedical Sciences

The Official Journal of Paramedical School, KUMS

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Frequency ofantibodies againstbloodgroup antigens in patient ofGhaem hospitalMashhad

Author(s):

Mohammad Hadi Sadeghian¹,

Seyede Fateme Shams^2,*,

Toktam Saneie²,

Seyed Masoud Alavi³,

Ahmad Ashjaee³,

Mohsen Dashti³

1Department of hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad‎, Iran

2Department of Medical Laboratory Sciences, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran

3Blood Bank, Mashhad University of Medical Sciences, Mashhad, Iran

Journal of Clinical Research in Paramedical Sciences:Vol. 1, issue 4; e82294

Published online:Jan 17, 2013

Article type:Research Article

Received:Jun 06, 2012

Accepted:Nov 12, 2012

How to Cite:Sadeghian M H, Shams S F, Saneie T, Alavi S M, Ashjaee A, et al. Frequency ofantibodies againstbloodgroup antigens in patient ofGhaem hospitalMashhad.J Clin Res Paramed Sci.2013;1(4):e82294.

Abstract

Introduction: Most blood group alloantibodies are generated by mismatched transfusion as
the result of foreign erythrocyte antigen exposure to the immune system. This study was done
to determine the frequency of blood group alloantibodies in patients who admitted in Ghaem
hospital of Mashhad-Iran.
Method: This cross sectional study was done on 525 patientsin Ghaem Hospital of Mashhad
University of Medical Sciences. The ABO and Rh Blood groups were typed by two methods
of cell type and back type. Red blood cell alloantibodies were detected in patients' serum by
screen antibody kit. All data recorded in computer and analyzed by SPSS version13.
Result: 296 of 525 patients were male and 229 of them were female. Red cell antibodies
were detected in 48 patients consisting one autoantibody and 47 alloantibodies. Warm
allantibodies found in 11 patients and cold alloantibodies detected in 36 patients.
Conclusion: Higher frequency of all immunization was observed in female in compare to
male. This study demonstrates the relationship between the type of blood group and existence
of cold alloantibody. The higher frequency of cold alloantibodies was in people with B blood
group type.

Keywords

alloantibody

auto antibody

antibody screening

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