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The Effect of Training (Aerobic and Concurrent) and Cinnamon Supplementation on the Plasma Levels of Visfatin and Adiponectin in Overweight Diabetic Men


avatar Mehdi Baigzadeh 1 , avatar Sedigeh Hossienpour Delavar 1 , * , avatar Hassan Safikhani ORCID 1

1 Department of Physical Education and Sport Science, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

How to Cite: Baigzadeh M, Hossienpour Delavar S, Safikhani H. The Effect of Training (Aerobic and Concurrent) and Cinnamon Supplementation on the Plasma Levels of Visfatin and Adiponectin in Overweight Diabetic Men. J Clin Res Paramed Sci. 2020;9(2):e90906.
doi: 10.5812/jcrps.90906.


Journal of Clinical Research in Paramedical Sciences: 9 (2); e90906
Published Online: July 25, 2020
Article Type: Research Article
Received: July 8, 2019
Revised: October 22, 2019
Accepted: April 5, 2020



Diabetes is one of the most prevalent diseases caused by metabolic disorders, which is considered as a major global challenge.


The aim of this study was to compare the effects of two aerobic and concurrent (aerobic and resistance training) training protocols with supplementation of cinnamon on the level of some selected adipokines (visfatin and adiponectin) in overweight men with type 2 diabetes.


for this purpose among The overweight and type II diabetic men in Kermanshah who were referred to a medical clinic, fifty people with BMI 28.55 ± 2.52 and age of 45.98 ± 6.79 who were volunteer to participate in research design, divided in five 10 people group consist of four experimental and one control group randomly. The experimental groups involve aerobic training, concurrent training, aerobic training along with cinnamon supplementation and eventually concurrent training along with cinnamon supplementation. While the experimental groups did the specific training, the control groups did no training throughout research design. Blood sampling were taken in experimental and control groups during pretest and posttest from anterior brachial vein. The variables were measured by ELISA method.


The results of ANCOVA and Bonferroni tests showed that both aerobic training and concurrent training (aerobic and resistance training) with and without cinnamon supplementation caused significant increase in plasma levels of adiponectin and significant decrease in plasma levels of visfatin in type two diabetic men.8 weeks of concurrent training in comparing with aerobic training was more effective in increasing the plasma levels of adiponectin and the difference between them was significant but the difference about plasma level of visfatin was insignificant.


The results of this study showed that the effect of both aerobic and concurrent training with and without cinnamon supplementation has significant effect on plasma levels of adiponectin and visfatin and except more increase in adiponectin level in concurrent group in comparing with aerobic group, nearly there are no differences in terms of training type and taking and no taking of cinnamon supplementation. Based the finding of this study, both aerobic and concurrent training especially with cinnamon supplementation is effective in improving the health of men with type 2 and overweight diabetes.

1. Background

Diabetes is one of the most prevalent diseases caused by metabolic disorders, which is considered as a major global challenge (1, 2). Type 2 diabetes involves a group of metabolic disorders that are characterized by hyperglycemia due to insufficient secretion of insulin, insulin resistance, or a combination of both (3). Evidence from clinical and experimental studies suggests that inflammation has an important role in the development of this problem (4). Because of the role of Adipose tissue as the source of inflammation, the relationship between obesity and type 2 diabetes, due to the production of cytokines is recent decades is more considered. The activation of adipokines triggers multiple responses. It repels insulin receptor after phosphorylation while at the same time adipokines activate other molecules that apply endocrine measures to different target tissues, including muscles, hypothalamus, and liver (5). Some adipokines, for example, the tumor necrosis factor-α (TNF-α) and IL-6 induces insulin resistance and inflammation (6), while other, for example, adiponectin and visfatin for glucose homeostasis and energy control is considered necessary (7, 8). According to the available research evidence, obesity is one of the health threats due to its association with metabolic and hormonal disorders such as lipid metabolism disorder, type two diabetes, cardiovascular disease and respiratory diseases (9). Based on the results of obesity studies and fat distribution in the body, especially in the central part (waist and abdomen), it is a strong predictor of metabolic disease. In fact, obesity can be described as a “new world syndrome”, which is considered to be the greatest health problem in the modern industrial and modern world (10). The prevalence of this disorder is increasing in all age groups in the world (10). Regular physical activity and optimal diet are factors that help prevent chronic illness by reducing fat levels, increasing insulin sensitivity, lowering blood pressure, and improving blood lipid profiles (11). In this regard, it seems that the introduction of well-designed training programs, favorable nutritional programs, and desired change in lifestyle can reduce the risk of developing vascular diseases (12, 13). However there are numerous finding about the effect of training on lipid metabolism in healthy subjects, the potential benefits of training on lipid metabolism in middle-aged people have been less widely considered. In this regard, studies have shown that the fitness program has a significant impact on the heath conditions of middle-aged people. This suggests that lipoprotein metabolism in aerobic training programs may increase.

Considering the role of obesity and its adipokaines in triggering some self-immune illness like type two diabetes and protective effect of training, some Studies have focused on the effect of physical activity and training on plasma lipokaines such as resistin, adiponectin and visfatine in human and animal samples. and in this area contradictory results have been reported. Among these, adiponectin and vidfatin are more investigated. Adiponectin is one of the most abundant hormone-like that secreted from adipose tissue, which, unlike others such as leptin and, resin, adipokines, is reduced in obesity (6). This hormone plays a major role in regulating the energy needed to maintain a homeostasis, fat and carbohydrate metabolism, and insulin sensitivity (6). Reported that aerobic training had no beneficial effects on serum adiponectin and resistin levels in obese women (14). On the other hand some studies reported that regular aerobic training, in addition to weight loss, body mass index, and fat percentage, reduced resin content and increased adiponectin in active subjects (15). The pivotal role of adiponectin in relation to the risk factors associated with metabolic syndrome, along with its anti-inflammatory effects, has been considered. Some studies have shown that reducing adiponectin concentration is associated with insulin resistance, hyperinsulinism, and hyperglycemia (15). In addition, various studies have reported an increase in adiponectin levels following weight loss and improved insulin resistance (16). According to the results, it seems that reducing adiponectin levels can be a major contributor to obesity and associated inflammatory disorders, including insulin resistance and type 2 diabetes. The results of studies indicate that increased concentration of plasma adiponectin leads to decreased insulin resistance, triglyceride, abdominal environment, abdominal/hip ratio, low-density lipoprotein, body fat mass, and high lipoprotein levels (15). Visfatine is one of the other important lipokine that its decrease such adiponectin has beneficial effects. It has been reported that visfatine has insulin-like properties (17) but it’s not clear that its acute and chronic changes how is affected by training and the results of study are limited and contradictory.

Today, special attention has been paid to various food additives. These compounds are important because they are herbal and are widely used in various dietary regimens. Cinnamon can be mentioned as herbs that seems to play an important role in the treatment and control of diabetes. It was reported in 1990 that cinnamon substances have insulin properties (18). One of the active ingredients derived from polymer cinnamon is hydroxyl methyl Kalkn, which acts like insulin (19). In type 2 diabetic patients, insulin receptor phosphorylation is reduced. On the other hand, cinnamon-soluble components inhibit insulin-receptor auto phosphorylation, a self-acting enzyme in the dephosphorylating of the receptor 2-insulin phosphatase (19). This itself increases insulin sensitivity. In some studies this has been shown that cinnamon can increase glucose catabolism by activating the insulin receptor and increasing glycogen synthesis (19).

Several studies have been carried out on the effects of various training methods (aerobic, resistance, concurrent) and its effective factors. Previous studies have found that intense training can increase the number of inflammatory cells, such as lymphocytes, monocytes, and neutrophils, all of which can release a wide range of cytokines and growth factors (20). Given the studies with contradictory results about the effect of physical training and training on blood adipokine, some studies have been done on the simultaneous assessment of aerobic and concurrent physical activity and diet modification. Considering that no research has been done on the effect of simultaneous use of cinnamon and aerobic and concurrent trainings on the level of adiponectin and visfatin serum level and the importance of using a better and more durable method to control the level of type 2 diabetes, which involves the use of cinnamon with aerobic and concurrent training, more research is required in this area.

2. Objectives

So the aim of this study was to measure the effect of aerobic and concurrent training with cinnamon on adiponectin and visfatin serum level in men with type 2 diabetes.

3. Methods

This is a experimental and applied study with pre and post-test, by four experimental groups, and one control group. The statistical population of the present study included overweight and type II diabetic men in Kermanshah who referred to a medical clinic. The statistical sample was 50 overweight men with type-2 diabetes mellitus voluntary participated in this research. The members of the samples were divided into experimental and control groups randomly. The subjects didn’t have any regular training experience in the past six mounts and with the control of investigators, avoid from any form of training except the study design training. Based on the clinical signs in the beginning of study, except of type II diabetes measured by fasting glucose (> 126), they were safe and in terms of body mass index (BMI)were in amplitude (> 25). In this study, initially the anthropometric indices of patients were measured so those abdominal and hip circumferences were measured at the most prominent point by an irreversible strip meter. The height of people without shoes and in a standing position was measured in such a way that the scapulars are tangent from the back with the wall. Weight and body fat percentage were recorded by using a body composition assay. The standing height and body weight were used to calculate body mass index. At the beginning of study, after completing the testimonial, questioner and physical activity level forms, subjects were randomly divided in five groups of 10 people. Five groups consist of aerobic training with placebo, aerobic training with cinnamon, concurrent with placebo, concurrent with cinnamon, and control group randomly. The cinnamon and placebo (strach) were consumed with subject in three 500 mg capsule per day while both had same shape, taste and smell. They have to follow their normal diet throughout study and avoid from any drugs and supplementation. Two day before the training course, the subjects after night rest and fasting state come to laboratory at 8 o’clock and 6 cc bloods was obtained from brachiocephalica vein. The samples were transferred under -4 to immediately to laboratory and with Wohan Chinese company hymen’s kit, by means of ELISA method measured.

While the experimental did their specific training protocols; the control group was banned from any form of training except normal daily activities. The training protocol for aerobic group was aerobic running by heart rate of 50 to 80 present of maximum heart rate (maximum heart rate = 220 -age). The training program was started by 20 minute and eventually was reached until 45 minute (21). Warm up and cooling down was performed for 5 minute at the beginning and the end of each session. The heart rate was controlled by polar barometer. the concurrent group did aerobic and resistance training alternately in each session. after 5 minute warm up, they first performed resistance training consist of two sets of twelve (2 × 12) by 70 percent of maximum strength calculated by the one maximum repetition equation (1 RM) 1 RM = weight (kg) × [1+ (0.033 × number of repetition)] for some selective multijoint resistance training. After resistance training, aerobic training consist of aerobic running was perfumed immediately by intensity of 50 to 70 percent of maximum heart rate. The total training time that begins from 20 minute and eventually reached to 45 minute was divided equally between two type of training e.g. aerobic and resistance training (22).

To analyze of data, in the descriptive analysis section, descriptive statistics indices such as mean and standard deviation were used and in inferential statistics, Shapiro-Wilk test was used to verify the natural distribution of data. The covariance and Bonferroni post hoc test was used to compare the groups. A significant level of 5% was considered in all calculations.

4. Results

Table 1 showed the descriptive data.

Table 1. Age and Body Composition of Subject in the Beginning of Studya
GroupAge, yBMI, kg/m2
Control (group 1)46.22 ± 7.2828.85 ± 2.75
Aerobic-placebo (group 2)44.36 ± 6.2527.92 ± 2.65
Aerobic-cinnamon (group 3)45.56 ± 6.1529.65 ± 2.35
Concurrent-placebo (group 4)46.42 ± 7.2228.52 ± 2.46
Concurrent-cinnamon (group 5)47.38 ± 7.0827.84 ± 2.42

aValues are expressed as mean ± SD.

Table 2 showed the normality of data by Shapiro-Wilk.

Table 2. The Results of Shapiro-Wilk Testa
Control (group 1)0.5940.123
Aerobic-placebo (group 2)0.9440.925
Aerobic-cinnamon (group 3)0.9590.408
Concurrent-placebo (group 4)0.8330.561
Concurrent-cinnamon (group 5)0.9560.274

aThe result of Shapiro-Wilk test showed the Adiponectin and visfatin in all group had normal distribution in all group in the beginning of study.

Tables 3 and 4 showed the change in research depended variables during pre to post-test are about the changing of the visfatin serum levels. The analysis of covariance and benferoni post hoc test showed there are significant difference between aerobic-cinnamon and aerobic-placebo with control group respectively (P = 0.056 and 0.001) but there is no significant difference between two experimental group (P = 0.088). In other world both groups similarly decrease the levels of visfatin. After 8 weeks of concurrent training the finding showed both concurrent-cinnamon and concurrent placebo had significant difference with control group (P = 0.001) and there is no significant difference between two experimental groups and the decreasing of visfatin levels was same in two experimental groups (P = 0.006).

Table 3. Blood Visfatin Value in Pre and Posttest (µg/ML)a, b
Control (group 1)8.53 ± 0.6198.514 ± 0.543
Aerobic-placebo (group 2)8.61 ± 0.6686.36 ± 0.465A
Aerobic-cinnamon (group 3)8.45 ± 0.6886.29 ± 0.939A
Concurrent-placebo (group 4)9.241 ± 0.7097.82 ± 0.803A
Concurrent-cinnamon (group 5)9.14 ± 0.5926.53 ± 0.658A

aValues are expressed as mean ± SD.

bA, is the sign off meaningful difference with control group (group 1) in the level of 0.05 ≥ α.

Table 4. Blood adiponectin value in pre and posttest (µg/ML)a, b
Control (group 1)14.71 ± 0.41514.75 ± 0.460
Aerobic-placebo (group 2)14.51 ± 0.43316.08 ± 0.445A
Aerobic-cinnamon (group 3)14.23 ± 0.36515.35 ± 0.782A, B
Concurrent-placebo (group 4)14.45 ± 0.50015.28 ± 0.815
Concurrent-cinnamon (group 5)14.52 ± 0.42116.567 ± 0.460

aValues are expressed as mean ± SD.

bA, is the sign off significant difference with control group; B, is the sign off significant difference with concurrent-cinnamon group (group 5) in the level of 0.05 ≥ α.

About the changing of the adiponectin serum levels, the analysis of covariance and benferoni post hoc test showed there are significant difference between aerobic-cinnamon and aerobic-placebo with control group respectively (P = 0.001 and 0.046) but there is no significant difference between two experimental group (P = 0.077). In other world both groups similarly increase the levels of adiponectin after 8 weeks of concurrent training the analysis of variance and benferoi post hoc test showed both concurrent-cinnamon and concurrent placebo had significant difference with control group (P = 0.001) and there is significant difference between two experimental groups and the increase of adiponectin was more in concurrent group (P = 0.001).

5. Discussion

The main purpose of this study was to compare the effect of eight weeks of aerobic and concurrent (aerobic and resistance) training with supplementation of cinnamon on the levels of some adipokines (visfatin and adiponectin) in obese patients men with type 2 diabetes. The results showed that both groups of eight weeks of concurrent and aerobic training without cinnamon had a significant decrease in visfatin levels as well as an increase in adiponectin levels. Meanwhile, the use of cinnamon had a significant effect on the increase in adiponectin levels. However, the results showed that the concurrent training group with cinnamon had a more increase on the level of adiponectin in obese men with type 2 diabetes compared to the placebo-concurrent training group. The results of this study were consistent with the results of Kardiatun et al. (23) and Lee et al. (24). In addition, the results of this study were not consistent with the results of Nassis et al. (14). Probably the reasons for non-alignment with the results of these studies may be due to differences in training time, training intensity, and age of participants, supplementation of cinnamon and other environmental factors.

Currently, it is well known that the obesity especially central type is a one of the factor that related with insulin resistance and metabolic syndrome (9). Studies identified visfatin as an important adipokine, which is mainly produced in the fat tissue of humans. Visfatin may facilitate glucose control. The visfatin levels were related to age, WHR and fasting insulin, while after multiple regression analysis, it was found that only WHR had a positive correlation with plasma visfatin levels (25). Sedentary lifestyle are associated with the most constituents of metabolic disorders, and physical activity is correlated with the reduction of obesity risk, type 2 diabetes and cardiovascular disease (25). Therefore, changes in levels of adipokines may be a fundamental key to identify the desirable effects of the activity. Choi et al. (25) studied the simultaneous effect of concurrent aerobic and resistance programs on 48 plasma levels of non-diabetic women aged 50 - 55 years with overweight or obesity. Subjects were non-active who normally did less than 20 minutes of training during a week. The applied training program was 5 sessions of weekly training for 12 weeks, each session had 45 minutes of aerobic activity and 20 minutes of resistance activity. Subsequently, after 12 weeks of training, the subjects lost weight from 4 to 5 kg, the percentage of fat, waist circumference, fasting glucose and visfatin levels. Therefore, the combination of aerobic and resistance programs and weight loss significantly reduced plasma visfatin levels of overweight or obese women. Braun et al. (26) also showed plasma levels of visfatin in two groups of obese and type 2 diabetic patients aged 45 - 45 years before and after 12 weeks aerobic training. The training was performed at an intensity equal to 75% of maximum aerobic power, 4 sessions per week and each session for 1 hour. At the end of the training program, the waist size of subjects with diabetes was decreased, the maximum aerobic power of obese subjects was increased and visfatin levels decreased in both groups.

The results of this research regarding the significant change (inter-group) of adiponectin in subjects was inconsistent with the results of Sirico et al. (15), and is consistent with some other types of research like Reynolds et al. study (27). In Reynold’s research, 10 weeks of concurrent training resulted in a significant improvement in plasma adiponectin levels in inactive postmenopausal women. Abbenhardt et al. (28) examined the effect of diet and training on adiponectin in women, and observed that adiponectin was significantly increased and this index was directly related to insulin sensitivity. Some other studies suggest no significant changes in adiponectin, including, Reynolds et al. (27) evaluated the effect of weight loss (training and diet) on glucose, insulin, and adiponectin in women overweight and obese after menopause. They concluded that weight loss did not change the plasma concentration of adiponectin while plasma glucose and insulin were significantly decreased. In another study, 16 weeks of concurrent training did not have a significant effect on plasma leptin and adiponectin concentrations and body mass index (BMI) and weight of postmenopausal women. A number of recent studies have shown that training affects the concentration of adiponectin in plasma. However, most of these studies did not report significant changes in the concentration of adiponectin after training despite the difference in practice protocols (a period of training, intermittent and endurance trainings), and intensity of training. It has also been shown that diet and sports training increase adiponectin (29). In some studies, the effect of training on adiponectin and insulin sensitivity in elderly diabetic patients was observed and significant changes were observed in adiponectin concentration during training (endurance, strength, and combination). As the effects of low calorie diet and moderate (concurrent) activity on adiponectin were observed in a study in elderly subjects with insulin resistance. The results showed that the insulin sensitivity index improved in all subjects, but adiponectin increased significantly only among diabetic subjects. Moreover the effect of cinnamon supplementation is added to effect of training in this study. Cinnamon has insulin like effect that improves insulin senility and resistance. In concurrent group, the effect of training and cinnamon added to each other add led to more decrease in adiponectin level in compared with aerobic and cinnamon group and concurrent group. It seems the total consumed calories in concurrent group is more and adiponectin in more effected by total calories in compare with visfatin.

5.1. Conclusions

The results of this research showed that the effect of separation training on the consumption or non-use of cinnamon in aerobic and combination methods used in this study had a significant effect on measured parameters including adiponectin and visfatin, which was effective in improving the health of overweight men with type 2 diabetes. On the other hand, the simultaneous use of cinnamon supplementation with concurrent training compared to aerobic training was more effective in increasing the amount of adiponectin. Generally, the results of this study showed that the effect of aerobic and concurrent activity (endurance-resistance) and cinnamon extract together have a synergistic effect and increasing in adiponectin. Therefore, based on the findings of this research, it is suggested that combination of aerobic and the use of cinnamon can be a suitable approach to control blood glucose in type 2 diabetes.



  • 1.

    Ades PA. A lifestyle program of exercise and weight loss is effective in preventing and treating type 2 diabetes mellitus: why are programs not more available? Preventive medicine. 2015;80:50-2. doi: 10.1016/j.ypmed.2015.03.014. [PubMed: 25818810].

  • 2.

    Madsen SM, Thorup AC, Overgaard K, Jeppesen PB. High intensity interval training improves glycaemic control and pancreatic β cell function of type 2 diabetes patients. PloS one. 2015;10(8). e0133286. [PubMed: 26258597].

  • 3.

    Kasumov T, Solomon TP, Hwang C, Huang H, Haus JM, Zhang R, et al. Improved insulin sensitivity after exercise training is linked to reduced plasma C 14: 0 ceramide in obesity and type 2 diabetes. Obesity. 2015;23(7):1414-21. doi: 10.1002/oby.21117. [PubMed: 25966363].

  • 4.

    Raman A. The role of exercise in glycaemic control and inflammation in overweight/obese individuals with and without type 2 diabetes. Murdoch University; 2018.

  • 5.

    Torres-Garcia R, Camarillo-Romero EDS, Majluf-Cruz A, Vázquez de Anda GF, Loe-Ochoa AM, Montenegro-Morales LP, et al. Effect of exercise on the serum concentrations of leptin and adiponectin in adolescents with risk factors of developing diabetes. Revista Médica del Instituto Mexicano del Seguro Social. 2018;55(6):708-14.

  • 6.

    de Castro CA, da Silva KA, Rocha MC, Sene-Fiorese M, Nonaka KO, Malavazi I, et al. Exercise and omentin: their role in the crosstalk between muscle and adipose tissues in type 2 diabetes mellitus rat models. Frontiers in physiology. 2018;9. doi: 10.3389/fphys.2018.01881. [PubMed: 30666216].

  • 7.

    Tsiotra PC, Halvatsiotis P, Patsouras K, Maratou E, Salamalekis G, Raptis SA, et al. Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus. Peptides. 2018;101:157-66. doi: 10.1016/j.peptides.2018.01.005. [PubMed: 29337272].

  • 8.

    Mir E, Fathi M. Changes in Plasma Visfatin and Insulin Resistance Index in Obese Women with Type 2 Diabetes after Pilates Exercise. Journal of Health and Care. 2018;20(1):30-9. doi: 10.29252/jhc.20.1.30.

  • 9.

    Roque FR, Hernanz R, Salaices M, Briones AM. Exercise training and cardiometabolic diseases: focus on the vascular system. Current hypertension reports. 2013;15(3):204-14. doi: 10.1007/s11906-013-0336-5. [PubMed: 23519745].

  • 10.

    Verma S, Hussain ME. Obesity and diabetes: an update. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2017;11(1):73-9. doi: 10.1016/j.dsx.2016.06.017. [PubMed: 27230949].

  • 11.

    Safdar A, Saleem A, Tarnopolsky MA. The potential of endurance exercise-derived exosomes to treat metabolic diseases. Nature Reviews Endocrinology. 2016;12(9):504. doi: 10.1038/nrendo.2016.76. [PubMed: 27230949].

  • 12.

    Goodpaster BH, Sparks LM. Metabolic flexibility in health and disease. Cell metabolism. 2017;25(5):1027-36. doi: 10.1016/j.cmet.2017.04.015. [PubMed: 28467922].

  • 13.

    Pereira RM, Botezelli JD, da Cruz Rodrigues KC, Mekary RA, Cintra DE, Pauli JR, et al. Fructose consumption in the development of obesity and the effects of different protocols of physical exercise on the hepatic metabolism. Nutrients. 2017;9(4):405. doi: 10.3390/nu9040405. [PubMed: 28425939].

  • 14.

    Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism. 2005;54(11):1472-9. doi: 10.1016/j.metabol.2005.05.013. [PubMed: 16253636].

  • 15.

    Sirico F, Bianco A, D'Alicandro G, Castaldo C, Montagnani S, Spera R, et al. Effects of physical exercise on adiponectin, leptin, and inflammatory markers in childhood obesity: systematic review and meta-analysis. Childhood Obesity. 2018;14(4):207-17. doi: 10.1089/chi.2017.0269. [PubMed: 29762052].

  • 16.

    Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. International journal of molecular sciences. 2017;18(6):1321. doi: 10.3390/ijms18061321. [PubMed: 28635626].

  • 17.

    Zarei M, Hamedinia M, Haghighi A, Noorafshar R, Amini S. Effect of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and visfatin levels in men with type 2 diabetes. Iranian Journal of Diabetes and Metabolism. 2016;16(1):63-76.

  • 18.

    Fayaz E, Damirchi A, Zebardast N, Babaei P. Co-Treatment of Cinnamon Extract with High-intensity Endurance Training Alleviates Metabolic Syndrome via Noncanonical WNT Signaling. Nutrition. 2019. doi: 10.1016/j.nut.2019.03.009. [PubMed: 31170681].

  • 19.

    Tangvarasittichai S, Sanguanwong S, Sengsuk C, Tangvarasittichai O. Effect of cinnamon supplementation on oxidative stress, inflammation and insulin resistance in patients with type 2 diabetes mellitus. Int J Toxicol Pharmacol Res. 2015;7(4):56-9.

  • 20.

    Simpson RJ, Kunz H, Agha N, Graff R. Exercise and the regulation of immune functions. Progress in molecular biology and translational science. 135. USA: Elsevier; 2015. p. 355-80.

  • 21.

    Yaribeygi H, Butler AE, Sahebkar A. Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications. Journal of cellular physiology. 2019;234(8):12508-15. doi: 10.1002/jcp.28110. [PubMed: 30623433].

  • 22.

    Silveira-Rodrigues JG, Perez DV, Aleixo IMS, Fonseca CG, Deresz LF, Soares DD, et al. Concurrent training improves the body composition of elderly type 2 diabetic patients treated with insulin. Journal of Physical Education and Sport. 2018;18(3):1661-8.

  • 23.

    Kardiatun T, Dibua UM, Badger-Emeka L, Ugonabo JA, Tirwomwe JF, Agwu E, et al. The effect of cinnamon on glucose control in patients with type 2 diabetes mellitus in Pontianak, Indonesia. International Journal of Medicine and Medical Sciences. 2013;5(10):434-7.

  • 24.

    Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of ethnopharmacology. 2004;92(1):1-21. doi: 10.1016/j.jep.2010.06.028.

  • 25.

    Choi KM, Kim JH, Cho G, Baik S, Park HS, Kim SM. Effect of exercise training on plasma visfatin and eotaxin levels. European journal of endocrinology. 2007;157(4):437-42. doi: 10.1530/EJE-07-0127. [PubMed: 17893257].

  • 26.

    Braun B, Zimmermann MB, Kretchmer N. Effects of exercise intensity on insulin sensitivity in women with non-insulin-dependent diabetes mellitus. Journal of Applied Physiology. 1995;78(1):300-6. doi: 10.1152/jappl.1995.78.1.300. [PubMed: 7713829].

  • 27.

    Reynolds IV TH, Supiano MA, Dengel DR. Regional differences in glucose clearance: effects of insulin and resistance training on arm and leg glucose clearance in older hypertensive individuals. Journal of Applied Physiology. 2007;102(3):985-91. doi: 10.1152/japplphysiol.00914.2006. [PubMed: 17122377].

  • 28.

    Abbenhardt C, McTiernan A, Alfano CM, Wener MH, Campbell KL, Duggan C, et al. Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels. Journal of internal medicine. 2013;274(2):163-75. doi: 10.1111/joim.12062. [PubMed: 23432360].

  • 29.

    Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE. Effect of cinnamon on glucose and lipid levels in Non–insulin-dependent type 2 diabetes. Diabetes care. 2007;30(9):2236-7. doi: 10.2337/dc07-0098. [PubMed: 17563345].

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