What Is Efficacy of Chloroquine/Hydroxychloroquine in Clinical Cure of SARS-CoV-2? Evidence from an Iranian Population

authors:

avatar Kiarash Ghazvini ORCID 1 , 2 , avatar Masoud Keikha ORCID 1 , 2 , 3 , *

Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

how to cite: Ghazvini K, Keikha M. What Is Efficacy of Chloroquine/Hydroxychloroquine in Clinical Cure of SARS-CoV-2? Evidence from an Iranian Population. J Health Rep Technol. 2021;7(1):e107362. https://doi.org/10.5812/ijhls.107362.

References

  • 1.

    Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259-60. [PubMed ID: 32139904]. [PubMed Central ID: PMC7095524]. https://doi.org/10.1038/s41569-020-0360-5.

  • 2.

    Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. https://doi.org/10.1016/s0140-6736(20)30566-3.

  • 3.

    Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020;382(10):929-36. [PubMed ID: 32004427]. [PubMed Central ID: PMC7092802]. https://doi.org/10.1056/NEJMoa2001191.

  • 4.

    Ghaebi M, Osali A, Valizadeh H, Roshangar L, Ahmadi M. Vaccine development and therapeutic design for 2019-nCoV/SARS-CoV-2: Challenges and chances. J Cell Physiol. 2020;235(12):9098-109. [PubMed ID: 32557648]. [PubMed Central ID: PMC7323389]. https://doi.org/10.1002/jcp.29771.

  • 5.

    Hu TY, Frieman M, Wolfram J. Insights from nanomedicine into chloroquine efficacy against COVID-19. Nat Nanotechnol. 2020;15(4):247-9. [PubMed ID: 32203437]. [PubMed Central ID: PMC7094976]. https://doi.org/10.1038/s41565-020-0674-9.

  • 6.

    Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20(5):269-70. [PubMed ID: 32273594]. [PubMed Central ID: PMC7143200]. https://doi.org/10.1038/s41577-020-0308-3.

  • 7.

    Yousefi B, Valizadeh S, Ghaffari H, Vahedi A, Karbalaei M, Eslami M. A global treatments for coronaviruses including COVID-19. J Cell Physiol. 2020;235(12):9133-42. [PubMed ID: 32394467]. [PubMed Central ID: PMC7273044]. https://doi.org/10.1002/jcp.29785.

  • 8.

    Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14(1):58-60. [PubMed ID: 32147628]. https://doi.org/10.5582/ddt.2020.01012.

  • 9.

    Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020;382(19):1787-99. [PubMed ID: 32187464]. [PubMed Central ID: PMC7121492]. https://doi.org/10.1056/NEJMoa2001282.

  • 10.

    Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020;30(3):269-71. [PubMed ID: 32020029]. [PubMed Central ID: PMC7054408]. https://doi.org/10.1038/s41422-020-0282-0.

  • 11.

    Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, et al. Drug targets for corona virus: A systematic review. Indian J Pharmacol. 2020;52(1):56-65. [PubMed ID: 32201449]. [PubMed Central ID: PMC7074424]. https://doi.org/10.4103/ijp.IJP_115_20.

  • 12.

    Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, et al. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J. 2005;2(1):1.

  • 13.

    Touret F, de Lamballerie X. Of chloroquine and COVID-19. Antiviral Res. 2020;177:104762. [PubMed ID: 32147496]. [PubMed Central ID: PMC7132364]. https://doi.org/10.1016/j.antiviral.2020.104762.

  • 14.

    Thome R, Moraes AS, Bombeiro AL, Farias Ados S, Francelin C, da Costa TA, et al. Chloroquine treatment enhances regulatory T cells and reduces the severity of experimental autoimmune encephalomyelitis. PLoS One. 2013;8(6). e65913. [PubMed ID: 23799062]. [PubMed Central ID: PMC3683039]. https://doi.org/10.1371/journal.pone.0065913.

  • 15.

    Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: The reality and challenges. J Microbiol Immunol Infect. 2020;53(3):436-43. [PubMed ID: 32307245]. [PubMed Central ID: PMC7129535]. https://doi.org/10.1016/j.jmii.2020.03.034.

  • 16.

    Singh AK, Singh A, Shaikh A, Singh R, Misra A. Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries. Diabetes Metab Syndr. 2020;14(3):241-6. [PubMed ID: 32247211]. [PubMed Central ID: PMC7102587]. https://doi.org/10.1016/j.dsx.2020.03.011.

  • 17.

    Huang M, Tang T, Pang P, Li M, Ma R, Lu J, et al. Treating COVID-19 with Chloroquine. J Mol Cell Biol. 2020;12(4):322-5. [PubMed ID: 32236562]. [PubMed Central ID: PMC7232130]. https://doi.org/10.1093/jmcb/mjaa014.

  • 18.

    Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care. 2020;57:279-83. [PubMed ID: 32173110]. [PubMed Central ID: PMC7270792]. https://doi.org/10.1016/j.jcrc.2020.03.005.

  • 19.

    Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020;71(15):732-9. [PubMed ID: 32150618]. [PubMed Central ID: PMC7108130]. https://doi.org/10.1093/cid/ciaa237.

  • 20.

    Karimi A, Rafiei Tabatabaei S, Rajabnejad M, Pourmoghaddas Z, Rahimi H, Armin S, et al. An Algorithmic Approach to Diagnosis and Treatment of Coronavirus Disease 2019 (COVID-19) in Children: Iranian Expert’s Consensus Statement. Arch Pediatr Infect Dis. 2020;8(2). https://doi.org/10.5812/pedinfect.102400.

  • 21.

    Ashraf MA, Shokouhi N, Shirali E, Davari-tanha F, Memar O, Kamalipour A, et al. COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes. medRxiv. 2020. https://doi.org/10.21203/rs.3.rs-26339/v1.

  • 22.

    Eghbali A, Shokrollahi S, Mahdavi NS, Mahdavi SA, Dabbagh A. COVID-19 in pediatric patients: A case series. J Cell Mol Anesth. 2020;5(1):3-5.

  • 23.

    Azarkish M, Laleh Far V, Eslami M, Mollazadeh R. Transient complete heart block in a patient with critical COVID-19. Eur Heart J. 2020;41(22):2131. [PubMed ID: 32285920]. [PubMed Central ID: PMC7184360]. https://doi.org/10.1093/eurheartj/ehaa307.

  • 24.

    Jamaati H, Dastan F, Tabarsi P, Marjani M, Saffaei A, Hashemian S. A Fourteen-day Experience with Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS): An Iranian Treatment Protocol. Iran J Pharm Res. 2020;19(1):31-6.

  • 25.

    Rahimzadeh G, Ekrami Noghabi M, Kadkhodaei Elyaderani F, Navaeifar MR, Enayati AA, Manafi Anari A, et al. COVID-19 Infection in Iranian Children: A Case Series of 9 Patients. J Pediatr Rev. 2020:139-44. https://doi.org/10.32598/jpr.8.2.139.

  • 26.

    Sahraei Z, Shabani M, Shokouhi S, Saffaei A. Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine. Int J Antimicrob Agents. 2020;55(4):105945. [PubMed ID: 32194152]. [PubMed Central ID: PMC7156117]. https://doi.org/10.1016/j.ijantimicag.2020.105945.

  • 27.

    Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;56(1):105949. [PubMed ID: 32205204]. [PubMed Central ID: PMC7102549]. https://doi.org/10.1016/j.ijantimicag.2020.105949.

  • 28.

    Sarma P, Kaur H, Kumar H, Mahendru D, Avti P, Bhattacharyya A, et al. Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis. J Med Virol. 2020;92(7):776-85. [PubMed ID: 32297988]. [PubMed Central ID: PMC7262144]. https://doi.org/10.1002/jmv.25898.

  • 29.

    Shamshirian A, Hessami A, Heydari K, Alizadeh-Navaei R, Ebrahimzadeh MA, George WY, et al. Hydroxychloroquine Versus COVID-19: A Periodic Systematic Review and Meta-Analysis. MedRxiv. 2020.