Abstract
Background: One of major disadvantages of streptokinase, a commonly administered thrombolytic agent, is provocation of hypersensitivity. Objective: To determine interactions of the complement and erythrocytes with streptokinase. Methods: The interactions were studied by the measurement of complement activation products C1S: C1:INH and C3b-P, using modified techniques by Auda et al (1990). The kinetics and dose response of streptokinase immune complexes binding to erythrocytes were studied by flowcytometry. Findings: The findings indicated that the binding of ICs to Es depended significantly on the extent of complement activation (P<0.001) and ICs dose of ICs (P<0.001). Conclusion: It can be concluded that the complement system and Es have a central role in preventing the hypersensitivity reactions, in particular type III (Immune complex disease).
Keywords
Immune complexes (ICs) Complement Streptokinase Erythrocytes (Es)
Copyright
© 2024, Journal of Inflammatory Diseases. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.